Regulation of cytochrome p450 by inflammatory mediators: why and how?
Regulation of cytochrome p450 by inflammatory mediators: why and how?
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发表时间：
2001-03
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通讯作者：
E. Morgan
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作者：
E. Morgan
在宿主对炎症或感染的反应期间，细胞色素P450酶的表达和活性在肝脏中下调，导致药物清除和毒素活化的改变。本文综述了近年来关于这种下调机制的研究，以及涉及的细胞因子和细胞类型。细胞色素P450下调的可能原因进行了讨论。
Expression and activities of cytochrome P450 enzymes are down-regulated in the liver during the host response to inflammation or infection, leading to alterations in drug clearance and toxin activation. This review focuses on recent studies on the mechanisms of this down-regulation, as well as the cytokines and cell types involved. Possible reasons for cytochrome P450 down-regulation are discussed.