IMPULSE CONDUCTION IN MULTIPLE-SCLEROSIS - THEORETICAL BASIS FOR MODIFICATION BY TEMPERATURE AND PHARMACOLOGICAL AGENTS
IMPULSE CONDUCTION IN MULTIPLE-SCLEROSIS - THEORETICAL BASIS FOR MODIFICATION BY TEMPERATURE AND PHARMACOLOGICAL AGENTS
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DOI：
10.1136/jnnp.37.2.152
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发表时间：
1974-01-01
影响因子：
11
通讯作者：
DAVIS, FA
中科院分区：
文献类型：
--
作者：
SCHAUF, CL;DAVIS, FA
解释多发性硬化症 (MS) 和其他脱髓鞘疾病中传导缺陷的最简单模型假设唯一存在的异常是髓磷脂缺失。这种假设的后果已经通过一组众所周知的描述脱髓鞘轴突模型传导的微分方程的数值求解来研究。与临床发现一致，我们表明该模型预测发生传导阻滞的温度是脱髓鞘程度的陡峭函数，因此小幅温度升高可能会阻碍大量传导纤维。降低钙浓度（或增加 pH 值）可显着提高脱髓鞘纤维的传导速度，此外还能恢复阻塞纤维的传导。还计算了其他药物的作用。神经纤维中脱髓鞘病变的存在极大地损害了纤维传导重复脉冲的能力，在比正常纤维低得多的频率下传导失败。这些计算提供了对脱髓鞘神经传导缺陷性质的一些见解，证明多发性硬化症的许多临床特征是髓磷脂缺失的预期结果，不需要其他缺陷的存在来解释，并为寻找对症治疗提供了一种有用的方法。
The simplest model for explaining conduction defects in multiple sclerosis (MS) and other demyelinating diseases assumes that the only abnormality present is loss of myelin. The consequences of such an assumption have been investigated by numerical solution of a well-known set of differential equations describing conduction in a model demyelinated axon. In agreement with clinical findings, we show that this model predicts that the temperature at which conduction block occurs is a steep function of the extent of demyelination, so that small temperature increases may block large numbers of conducting fibres. Decreasing calcium concentration (or increasing pH) is calculated markedly to improve the conduction velocity of conducting demyelinated fibres and will, in addition, restore conduction in blocked fibres. The effects of other pharmacological agents have also been computed. The presence of a demyelinating lesion in a nerve fibre is shown greatly to impair the ability of the fibre to conduct repetitive impulses, conduction failing at much lower frequencies than in normal fibres. These calculations provide some insight into the nature of conduction defects in demyelinated nerve, demonstrate that many clinical features of MS are the expected consequence of loss of myelin and do not require the presence of other defects for their explanation, and provide a useful approach to the search for a symptomatic therapy.