Comparative study of trichloroacetic acid vs. photodynamic therapy with topical 5-aminolevulinic acid for actinic keratosis of the scalp
Comparative study of trichloroacetic acid vs. photodynamic therapy with topical 5-aminolevulinic acid for actinic keratosis of the scalp
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DOI：
10.1111/phpp.12164
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发表时间：
2015-09-01
影响因子：
2.6
通讯作者：
Pagliarello, Calogero
中科院分区：
文献类型：
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作者：
Di Nuzzo, Sergio;Cortelazzi, Chiara;Pagliarello, Calogero
背景光动力疗法（5-甲基氨基乙酰丙酸）和光动力疗法（50%三氯乙酸）是治疗光化性角化病的两种技术。本研究计划比较的疗效，不良反应，复发和美容效果的这些选项治疗的患者与多发性光化性角化病的scale.MethodsThirteen患者与多发性光化性角化病进行了治疗的两个治疗的一半头皮在基线，而另一种治疗方法进行了另一半15天，随机。结果5-甲基氨基酮戊酸光动力疗法的疗效优于三氯乙酸，但患者对5-甲基氨基酮戊酸光动力疗法的耐受性较三氯乙酸差。早期不良反应几乎相同，即使三氯乙酸也导致结痂形成和以色素减退为特征的更差的美容结果。复发率较低，在该地区与光动力therapeutic.ConclusionTrichloroacetic acid 50%是有效的，比光动力疗法与5甲基氨基乙酰丙酸在治疗多发性光化性角化病的头皮，虽然更好地耐受患者。由于这种技术比光动力疗法更少痛苦和更便宜，我们假设并建议更多的连续治疗可能会导致更好的结果。
BackgroundPhotodynamic therapy with 5-methyl-aminolevulinate and photodynamic therapy with trichloroacetic acid 50% are the two techniques utilized in the management of actinic keratosis. This study was planned to compare the efficacy, adverse effects, recurrence and cosmetic outcome of these option therapies in patients with multiple actinic keratosis of the scalp.MethodsThirteen patients with multiple actinic keratosis were treated with one of the two treatments on half of the scalp at baseline, while the other treatment was performed on the other half 15days apart, randomly. Efficacy, adverse effects, cosmetic outcome and recurrence were recorded at follow-up visit at 1, 3, 6 and 12months.ResultsPhotodynamic therapy with 5 methyl-aminolevulinate was more effective than trichloroacetic acid although less tolerated by patients as it was more painful. Early adverse effects were almost the same even if trichloroacetic acid leads also to crust formation and to a worse cosmetic outcome characterized by hypopigmentation. Recurrence was lower in the area treated with photodynamic therapy.ConclusionTrichloroacetic acid 50% is less effective than photodynamic therapy with 5 methyl-aminolevulinate in the treatment of multiple actinic keratosis of the scalp although better tolerated by patients. As this technique is less painful and less expensive than photodynamic therapy, we hypothesize and suggest that more sequential treatments could lead to better results.