Posterior Hypoperfusion in Parkinson's Disease With and Without Dementia Measured With Arterial Spin Labeling MRI
Posterior Hypoperfusion in Parkinson's Disease With and Without Dementia Measured With Arterial Spin Labeling MRI
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DOI：
10.1002/jmri.22515
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发表时间：
2011-04-01
影响因子：
4.4
通讯作者：
Hattori, Nobutaka
中科院分区：
文献类型：
--
作者：
Kamagata, Koji;Motoi, Yumiko;Hattori, Nobutaka
目的：探讨定量动脉自旋标记(ASL)技术在帕金森病痴呆(PDD)和非痴呆(PD)患者局部脑血流检测中的应用价值。材料与方法：对35例PD患者、11例PDD患者和35例正常对照进行ASL扫描。结果：PD和PDD患者后部皮质局部脑血流量低于正常对照组(P=0.002和P=0.001，采用Bonferroni后检验进行方差分析)。结论：这是首次利用ASL灌注磁共振发现PD和PDD患者后部皮质局部脑血流量降低。由于ASL灌注MRI是完全无创的，因此可以安全地用于重复评估，该方法可用于监测帕金森病的治疗效果或疾病进展。
Purpose: To determine whether quantitative arterial spin labeling (ASL) can be used to evaluate regional cerebral blood flow in Parkinson's disease with dementia (PDD) and without dementia (PD).Materials and Methods: Thirty-five PD patients, 11 PDD patients, and 35 normal controls were scanned by using a quantitative ASL method with a 3 Tesla MRI unit. Regional cerebral blood flow was compared in the posterior cortex using region-of-interest analysis.Results: PD and PDD patients showed lower regional cerebral blood flow in the posterior cortex than normal controls (P = 0.002 and P = 0.001, respectively, analysis of variance with a Bonferroni post hoc test).Conclusion: This is the first study to detect hypoperfusion in the posterior cortex in PD and PDD patients using ASL perfusion MRI. Because ASL perfusion MRI is completely noninvasive and can, therefore, safely be used for repeated assessments, this method can be used to monitor treatment effects or disease progression in PD.