The Role of Urinary Calcium and Chitotriosidase in a Cohort of Chronic Sarcoidosis Patients
The Role of Urinary Calcium and Chitotriosidase in a Cohort of Chronic Sarcoidosis Patients
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DOI：
10.1159/000505653
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发表时间：
2020-03-01
期刊：
影响因子：
3.7
通讯作者：
Caffarelli, Carla
中科院分区：
文献类型：
--
作者：
Cameli, Paolo;Gonnelli, Stefano;Caffarelli, Carla
背景：钙代谢改变在结节病中很常见，并与疾病活动性相关。目的：探讨慢性结节病患者钙代谢改变的临床意义。我们特别注意与特定疾病表型和壳三糖苷酶（CTO）表达的关联。方法：回顾性招募212例慢性结节病患者（平均年龄56.07 ± 12岁; 97例男性）。将人口统计学、临床、功能和放射学数据以及血清-尿钙代谢输入电子数据库进行分析。检测CTO和血管紧张素转换酶（ACE）水平，并进行骨密度和肺功能检查。结果：高钙尿和高钙血症分别在18.8%和1.8%的患者中观察到。尿钙水平与CTO活性相关（r = 0.33，p = 0.0042）。病情持续恶化的患者尿钙水平最高。肺一氧化碳弥散量（D-LCO）百分比与尿钙呈负相关（r = 0.1482; p = 0.0397）。结论：结节病患者存在钙代谢异常，尤其是高钙尿。尿钙与临床状态、D-LCO和血清CTO活性相关，提示其作为结节病活动和严重程度的生物标志物的潜在作用。
Background: Calcium metabolism alterations are quite common in sarcoidosis and have been correlated with disease activity. Objectives: The aim of the study was to investigate the clinical significance of calcium metabolism alterations in patients with chronic sarcoidosis. We paid particular attention to associations with specific disease phenotypes and chitotriosidase (CTO) expression. Methods: 212 chronic sarcoidosis patients (mean age 56.07 +/- 12 years; 97 males) were retrospectively recruited. Demographic, clinical, functional, and radiological data, and serum-urinary calcium metabolism were entered into an electronical database for analysis. Levels of CTO and angiotensin-converting enzyme (ACE) were measured and bone mineral density and lung function tests were conducted. Results: Hypercalciuria and hypercalcemia were observed in 18.8 and 1.8% of patients, respectively. Urinary calcium levels correlated with CTO activity (r = 0.33, p = 0.0042). Patients with worsening persistent disease showed the highest levels of urinary calcium. Diffusing capacity of the lung for carbon monoxide (D-LCO) percentage correlated inversely with urinary calcium (r = 0.1482; p = 0.0397). Conclusions: Calcium metabolism alteration, particularly hypercalciuria, was observed in a significant percentage of patients of sarcoidosis. Urinary calcium was correlated with clinical status, D-LCO, and serum CTO activity, suggesting its potential role as a biomarker of the activity and severity of sarcoidosis.