Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment.
Brain-derived neurotrophic factor serum levels correlate with cognitive performance in Parkinson's disease patients with mild cognitive impairment.
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DOI：
10.3389/fnbeh.2015.00253
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发表时间：
2015
影响因子：
3
通讯作者：
Angelucci F
中科院分区：
文献类型：
--
作者：
Costa A;Peppe A;Carlesimo GA;Zabberoni S;Scalici F;Caltagirone C;Angelucci F
脑源性神经营养因子是一种调节细胞存活和突触可塑性的营养因子。最近的研究结果表明，在正常和/或神经病理条件下，BDNF可能是认知功能的潜在调节因子。关于神经紊乱，最近的数据表明帕金森氏病(PD)患者可能受到认知缺陷的影响，他们改变了BDNF的产生。因此，可以提出这样的假设，即BDNF水平与这些患者的认知状态有关。有鉴于此，本研究旨在探讨伴有轻度认知障碍(MCI)的PD患者血清BDNF水平与认知功能的关系。13例帕金森病合并MCI患者纳入研究。他们接受了广泛的神经心理测试，调查了执行、情景记忆、注意力、视觉空间和语言领域。通过对属于特定领域的测试中的z分数进行平均，得到每个认知领域的单一分数。采用双抗体夹心酶联免疫分析法(ELISA)检测血清BDNF水平。对血清BDNF水平与认知成绩进行了Pearson相关分析。结果显示，BDNF血清水平与注意领域(p<；0.05)和执行领域(p<；0.05)均呈显著正相关。此外，在执行领域，我们发现BDNF水平与评估工作记忆和自我监控/抑制测试的分数之间存在显著的相关性。这些初步数据表明，BDNF血清水平与PD合并MCI患者的认知状态有关。鉴于BDNF在调节突触可塑性中的作用，目前的发现进一步支持了这种营养因子可能是评估帕金森病认知改变和其他与认知功能下降相关的神经综合征的潜在生物标志物的假说。
Brain-derived neurotrophic factor (BDNF) is a trophic factor regulating cell survival and synaptic plasticity. Recent findings indicate that BDNF could be a potential regulatory factor for cognitive functioning in normal and/or neuropathological conditions. With regard to neurological disorders, recent data suggest that individuals with Parkinson’s disease (PD) may be affected by cognitive deficits and that they have altered BDNF production. Therefore, the hypothesis can be advanced that BDNF levels are associated with the cognitive state of these patients. With this in mind, the present study was aimed at exploring the relationship between BDNF serum levels and cognitive functioning in PD patients with mild cognitive impairment (MCI). Thirteen PD patients with MCI were included in the study. They were administered an extensive neuropsychological test battery that investigated executive, episodic memory, attention, visual-spatial and language domains. A single score was obtained for each cognitive domain by averaging z-scores on tests belonging to that specific domain. BDNF serum levels were measured by enzyme-linked immunoassay (ELISA). Pearson’s correlation analyses were performed between BDNF serum levels and cognitive performance. Results showed a significant positive correlation between BDNF serum levels and both attention (p < 0.05) and executive (p < 0.05) domains. Moreover, in the executive domain we found a significant correlation between BDNF levels and scores on tests assessing working memory and self-monitoring/inhibition. These preliminary data suggest that BDNF serum levels are associated with cognitive state in PD patients with MCI. Given the role of BDNF in regulating synaptic plasticity, the present findings give further support to the hypothesis that this trophic factor may be a potential biomarker for evaluating cognitive changes in PD and other neurological syndromes associated with cognitive decline.