Functional organization of climbing fibre projection to the cerebellar anterior lobe of the rat
Functional organization of climbing fibre projection to the cerebellar anterior lobe of the rat
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DOI：
10.1111/j.1469-7793.2000.00297.x
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发表时间：
2000-01-15
影响因子：
5.5
通讯作者：
Luo, XL
中科院分区：
文献类型：
--
作者：
Jörntell, H;Ekerot, CF;Luo, XL
1.研究了电刺激皮肤不同部位诱发的爬升纤维场电位在巴比妥酸麻醉大鼠小脑的输入特点和分布。在横跨前叶内侧宽度的矢状定向微电极轨道上记录到攀升纤维反应。具有相似反应潜伏期和会聚模式的攀升纤维终止于宽度为0.5-1.5 mm的矢状带。前叶的主要组织结构在输入特征和矢状带位置方面与猫和雪貂相似。因此，将大鼠的矢状带暂时命名为a、b、c1、c2和d1区。与猫和雪貂不同，大鼠的a区以同侧爬行纤维的短潜伏期为特征。此外，它还可分为内侧“A1”区和外侧“AX”区，前者具有汇聚的近端输入，后者具有躯体组织的输入。发现了一个前肢区，其位置和输入特征与CAT的X区相似，但它构成了AX区的组成部分。同侧短潜伏期攀升纤维传入的躯体组织也在C1区被发现。在吻侧前叶，从同侧体的短潜伏期激活的攀爬纤维终止于体位有组织的横带，该横带从前叶的中线延伸到外侧端。C3和Y区的缺失可能被解释为反映了与猫相比，大鼠运动系统的组织结构上的差异。猫的熟练运动是通过前间插核由C1、C3和Y区控制的，而在大鼠则可能是通过顶核的吻外侧部由AX区部分控制的。
1. The input characteristics and distribution of climbing fibre field potentials evoked by electrical stimulation of various parts of the skin were investigated in the cerebellum of barbiturate anaesthetized rats. Climbing fibre responses were recorded in sagittally oriented microelectrode tracks across the mediolateral width of the anterior lobe.2. Climbing fibres with similar response latencies and convergence patterns terminated in sagittal bands with widths of 0.5-1.5 mm. The principal organization of the anterior lobe with respect to input characteristics and locations of sagittal zones was similar to that in the cat and ferret. Hence, the sagittal bands in the rat were tentatively named the a, b, c1, c2 and d1 zones.3. In contrast to the cat and ferret, the a zone of the rat was characterized by short latency ipsilateral climbing fibre input. Furthermore, it was divisible into a medial 'a1' zone with convergent, proximal input and a lateral 'ax' zone with somatotopically organized input. A forelimb area with similar location and input characteristics as the X zone of the cat was found, but it formed an integral part of the ax zone. A somatotopic organization of ipsilateral, short latency climbing fibre input was also found in the c1 zone.4. Rostrally in the anterior lobe, climbing fibres activated at short latencies from the ipsilateral side of the body terminated in a somatotopically organized transverse band which extended from the midline to the lateral end of the anterior lobe.5. The absence of the C3 and Y zones may be interpreted as a reflection of differences in the organization of the motor systems in the rat as compared with the cat. Skilled movements, which in the cat are controlled by the C1, C3 and Y zones via the anterior interposed nucleus, may in the rat be partly controlled by the ax zone via the rostrolateral part of the fastigial nucleus.