Local and systemic total antioxidant capacity in periodontitis and health
Local and systemic total antioxidant capacity in periodontitis and health
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DOI：
10.1111/j.1600-051x.2004.00509.x
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发表时间：
2004-07-01
影响因子：
6.7
通讯作者：
Chapple, ILC
中科院分区：
文献类型：
--
作者：
Brock, GR;Butterworth, CJ;Chapple, ILC
背景：活性氧簇(ROS)在牙周病变中的作用尚不清楚，但将受到体内抗氧化防御系统的调节。这项横断面研究的目的是测定局部(唾液和牙龈沟液)和外周(血浆和血清)抗氧化能力在牙周健康和疾病中的作用。材料和方法：20名不吸烟的慢性牙周炎志愿者和20名年龄和性别匹配的非吸烟对照。隔夜禁食后，采集唾液(完全未刺激和刺激)和血液。结果：GCF抗氧化剂浓度显著低于对照组(P<0.05)。
Background: The involvement of reactive oxygen species (ROS) in periodontal pathology is unclear but will be modulated by in vivo antioxidant defence systems. The aim of this cross-sectional study was to determine both local (saliva and gingival crevicular fluid (GCF) and peripheral (plasma and serum) antioxidant capacity in periodontal health and disease.Materials and Methods: Twenty non-smoking volunteers with chronic periodontitis were sampled together with twenty age- and sex-matched, non-smoking controls. After overnight fasting, saliva (whole unstimulated and stimulated) and blood were collected. Total antioxidant capacity (TAOC) was determined using a previously reported enhanced chemiluminescence method.Results: GCF antioxidant concentration was significantly lower (p