Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy
Systemic immunological changes induced by administration of grass pollen allergens via the oral mucosa during sublingual immunotherapy
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DOI：
10.1159/000024270
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发表时间：
1999-11-01
影响因子：
2.8
通讯作者：
Ebner, C
中科院分区：
文献类型：
--
作者：
Fanta, C;Bohle, B;Ebner, C
对24例草花粉过敏患者进行标准化草花粉提取物舌下免疫治疗（SLIT） 1年。为了研究经口腔黏膜给药致敏原引起的免疫变化，采用SLIT-spit法。主要过敏原（草5组过敏原）的累积剂量约为80 μ g，相对较低。在治疗期间，我们可以观察到特异性IgG和IgG4抗体水平明显升高。然而，在SLIT过程中，过敏原特异性IgE抗体的滴度也显着增加。分析淋巴细胞的增生性反应，发现全草花粉提取物刺激（p = 0.001）和重组Phl p1 （timothygrass的主要过敏原，p . 0.001）的反应性显著降低
Twenty-four patients suffering from grass pollen allergy underwent sublingual immunotherapy (SLIT) with standardized grass pollen extract for 1 year. In order to investigate immunological changes induced by the administration of allergens via the oral mucosa, the SLIT-spit method was applied. The cumulative dose of approximately 80 mu g of major allergen (grass group 5 allergen), was relatively low. During the time of treatment, we could observe a significant increase in the levels of specific IgG and IgG4 antibodies. However, the titers of allergen-specific IgE antibodies showed a significant increase in the course of SLIT as well. Analyzing lymphoproliferative responses, a significant decrease in reactivity in response to stimulation with complete grass pollen extract (p = 0.001) and to recombinant Phl p 1 (a major allergen of timothy grass, p