A Murine Model of Full-Thickness Scald Burn Injury with Subsequent Wound and Systemic Bacterial Infection.
A Murine Model of Full-Thickness Scald Burn Injury with Subsequent Wound and Systemic Bacterial Infection.
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DOI：
10.1007/978-1-0716-1488-4_10
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发表时间：
2021
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感染是严重烧伤患者在创伤急性期存活下来后死亡和延长住院时间的主要原因。在这里，我们描述了一个严重烧伤继发烧伤后感染的小鼠模型，包括局部和全身感染，导致脓毒症。详细描述了烫伤全层烧伤的过程，随后描述了两种常见的烧伤相关医院病原体，铜绿假单胞菌和金黄色葡萄球菌的感染。
Infection is the leading cause of death and prolonged hospitalization in severely burned patients that survive the acute phase of injury. Here we describe a murine model of severe burn injury followed by subsequent postburn infection, both local and systemic, that leads to sepsis. A detailed description of the full-thickness scald burn procedure is provided, followed by description of infection with two common burn-associated nosocomial pathogens, Pseudomonas aeruginosa and Staphylococcus aureus.