COMPARISON OF EFFECTS OF HIGH-DOSE AND LOW-DOSE ASPIRIN ON RESTENOSIS AFTER FEMOROPOPLITEAL PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY
COMPARISON OF EFFECTS OF HIGH-DOSE AND LOW-DOSE ASPIRIN ON RESTENOSIS AFTER FEMOROPOPLITEAL PERCUTANEOUS TRANSLUMINAL ANGIOPLASTY
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DOI：
10.1161/01.cir.91.8.2167
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发表时间：
1995-04-15
期刊：
影响因子：
37.8
通讯作者：
EHRINGER, H
中科院分区：
文献类型：
--
作者：
MINAR, E;AHMADI, A;EHRINGER, H
背景 建议患有大血管外周动脉疾病的患者长期使用阿司匹林治疗，因为这些患者因心血管原因死亡的风险很高。最近的研究表明，低剂量阿司匹林在降低心血管事件风险方面具有预防作用。由于阿司匹林也被推荐用于预防周围血管成形术后晚期复发，因此本研究旨在比较高剂量（1000 mg/d）和低剂量（100 mg/d）阿司匹林对股腘血管成形术后长期通畅的影响。 方法和结果 216 例经皮腔内血管成形术成功治疗股腘病变的患者被随机分配接受以下治疗：每天 1000 或 100 毫克阿司匹林。随访时间为24个月。使用Kaplan-Meier 方法分析长期结果，并使用Wilcoxon 和对数秩统计确定累积通畅曲线之间的差异。 207 名患者获得了完整的随访信息（24 个月后通畅、再狭窄和死亡）。在 2 年随访期间，72 名患者（高剂量阿司匹林组 36 名，低剂量阿司匹林组 36 名）分别在再通段内出现经血管造影证实的再梗阻。通过意向治疗分析，24 个月时的累积通畅率，高剂量阿司匹林组为 62.5%，低剂量阿司匹林组为 62.6%（Wilcoxon，P=.97；对数秩，P=.97）。随访 24 个月时，高剂量阿司匹林组的累积生存率为 86.6%，低剂量阿司匹林组的累积生存率为 87.7%。高剂量阿司匹林组中止治疗的患者人数为 30 人，低剂量阿司匹林组中止治疗的患者人数为 11 人（P
Background Long-term treatment with aspirin is recommended in patients with large-vessel peripheral arterial disease since these patients have a high risk of death from cardiovascular causes. Recent studies have demonstrated the prophylactic effect of low-dose aspirin in reducing the risk of cardiovascular events. Since aspirin is also recommended for prevention of late recurrence after peripheral angioplasty, the present study was undertaken to compare the effects of high-dose (1000 mg/d) and low-dose (100 mg/d) aspirin on long-term patency after femoropopliteal angioplasty.Methods and Results Two hundred sixteen patients treated successfully by percutaneous transluminal angioplasty for femoropopliteal lesions were randomly allocated to therapy with either 1000 or 100 mg aspirin daily. The follow-up was 24 months. The long-term results were analyzed using the Kaplan-Meier method, and differences between curves of cumulative patency were determined with the Wilcoxon and log-rank statistics. Complete follow-up information (patency after 24 months, restenosis, and death) was obtained in 207 patients. During the 2-year follow-up period, 72 patients-36 in the high-dose and 36 in the low-dose aspirin group, respectively-developed angiographically verified reobstruction within the recanalized segment. By intention-to-treat analysis, the cumulative patency rates at 24 months were 62.5% in the high-dose and 62.6% in the low-dose aspirin group (Wilcoxon, P=.97; log-rank, P=.97). The cumulative survival at 24 months of follow-up was 86.6% in the high-dose and 87.7% in the low-dose aspirin group. The number of patients discontinuing therapy was 30 in the high-dose and 11 in the low-dose aspirin group (P