Reduced Lean Body Mass and Cardiometabolic Diseases in Adult Males with Overweight and Obesity: A Pilot Study
Reduced Lean Body Mass and Cardiometabolic Diseases in Adult Males with Overweight and Obesity: A Pilot Study
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DOI：
10.3390/ijerph15122754
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发表时间：
2018-12-01
影响因子：
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通讯作者：
El Ghoch, Marwan
中科院分区：
文献类型：
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作者：
Khazem, Shirine;Itani, Leila;El Ghoch, Marwan
关于瘦体重（LBM）的减少及其对超重和肥胖的健康后果，特别是在男性中，知之甚少。因此，我们旨在评估低LBM在超重和肥胖寻求治疗的成年男性中的患病率以及与心脏代谢疾病的相关性，即，2型糖尿病、心血管疾病和血脂异常。通过生物阻抗分析仪（InBody 170）对总计110名男性进行了身体成分评估，其中72名超重和肥胖，并被转诊至黎巴嫩的贝鲁特阿拉伯大学（BAU）营养和饮食学系门诊部，38名年龄相仿的正常体重参与者。然后将超重和肥胖的参与者分类为具有或不具有低LBM。在72名参与者的样本中，50名（69.4%）符合LBM减少的标准，并显示出心脏代谢疾病的患病率显著较高（即，2型糖尿病、心血管疾病和血脂异常）的比例高于LBM正常的患者（36.0% vs. 9.1%; p = 0.019）。逻辑回归分析显示，在调整总脂肪和中心性肥胖后，低LBM使患有心脏代谢疾病的几率增加近550%（比值比（OR）= 5.46，95%置信区间（CI）= 1.31-26.39，p < 0.05）。寻求治疗的超重和肥胖成年男性显示出LBM减少的普遍性，这似乎与心血管和代谢疾病密切相关。
Little is known about the reduction in lean body mass (LBM) and its health consequences in overweight and in obesity, especially in males. Therefore, we aimed to assess the prevalence of low LBM in treatment-seeking adult males with overweight and obesity and the association with cardiometabolic diseases, i.e., type 2 diabetes, cardiovascular diseases and dyslipidemia. A body composition assessment was conducted by a bio-impedance analyzer (InBody 170) among a total of 110 males, of whom 72 were overweight and obese and were referred to the Outpatient Clinic in the Department of Nutrition and Dietetics at Beirut Arab University (BAU) in Lebanon, and 38 were normal-weight participants of similar ages. The participants with overweight and obesity were then categorized as being with or without low LBM. Of the sample of 72 participants, 50 (69.4%) met the criteria for reduced LBM and displayed a significantly higher prevalence of cardiometabolic diseases (i.e., type 2 diabetes, cardiovascular diseases and dyslipidemia) than those with normal LBM (36.0% vs. 9.1%; p = 0.019). Logistic regression analysis showed that low LBM increases the odds of having cardiometabolic diseases by nearly 550% (odds ratio (OR) = 5.46, 95% confidence interval (CI) = 1.31-26.39, p < 0.05) after adjusting for total fat and central adiposity. Treatment-seeking adult males with overweight and obesity displayed a great prevalence of reduced LBM, which seems to be strongly associated with cardiovascular and metabolic diseases.