Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.
Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid.
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DOI：
10.1002/mc.22201
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发表时间：
2015-11
影响因子：
4.6
通讯作者：
Chen T
中科院分区：
文献类型：
--
作者：
Lian CG;Xu S;Guo W;Yan J;Frank MY;Liu R;Liu C;Chen Y;Murphy GF;Chen T
The level of 5-hydroxymethylcytosine (5-hmC) converted by ten-eleven translocation (TET) family is decreased in cancers. However, whether 5-hmC level is perturbed in early stages of carcinogenesis caused by genotoxic carcinogens is not defined. 5-hmC levels and TET2 expression were measured in liver of rats treated with genotoxic carcinogens, riddelliine, or aristolochic acid. Levels of 5-hmC and TET2 expression decreased in the liver of the carcinogens-treated rats. Loss of 5-hmC correlates well with documented induction of genetic mutations by the carcinogens, suggesting that TET2-mediated 5-hydroxymethylation plays an epigenetic role in early state of carcinogenesis.
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影响因子：
4.1
作者：
Chou, MW;Jian, Y;Fu, PP
通讯作者：
Fu, PP
影响因子：
3.7
作者：
Liu C;Liu L;Chen X;Shen J;Shan J;Xu Y;Yang Z;Wu L;Xia F;Bie P;Cui Y;Bian XW;Qian C
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Qian C
影响因子：
11.2
作者：
Jin SG;Jiang Y;Qiu R;Rauch TA;Wang Y;Schackert G;Krex D;Lu Q;Pfeifer GP
通讯作者：
Pfeifer GP
影响因子：
3.5
作者：
Chan, PC;Haseman, JK;Nyska, A
通讯作者：
Nyska, A
影响因子：
3.8
作者：
Hong, HL;Ton, TV;Sills, RC
通讯作者：
Sills, RC