DEPLETION OF UNILATERAL STRIATAL DOPAMINE IMPAIRS INITIATION OF CONTRALATERAL ACTIONS AND NOT SENSORY ATTENTION
DEPLETION OF UNILATERAL STRIATAL DOPAMINE IMPAIRS INITIATION OF CONTRALATERAL ACTIONS AND NOT SENSORY ATTENTION
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DOI：
10.1038/313679a0
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发表时间：
1985-01-01
期刊：
影响因子：
64.8
通讯作者：
ROBBINS, TW
中科院分区：
文献类型：
--
作者：
CARLI, M;EVENDEN, JL;ROBBINS, TW
虽然帕金森氏病传统上被认为是一种运动障碍1,2，但最近人们对帕金森氏痴呆和认知功能障碍的性质和神经基质产生了很大的兴趣。这些障碍可诱发视觉空间障碍5和视觉“忽视”6，也可能与黑质纹状体多巴胺（DA）投射和基底神经节正常功能的争议有关，7-9。观察到黑质和纹状体中的神经元在神经元放电10,11或DA释放12,13方面对感觉事件作出反应，也表明纹状体在感觉运动整合中起作用。这种整合的一个重要行为关联是“感觉运动忽视”综合征14，发生在单侧黑质纹状体投射损伤的动物身上，这些动物无法定向到对侧感觉事件。然而，这种忽视可能不是由对侧感觉不注意引起的14,15，而是由于无法通过运动输出来表达这种感觉选择。我们在这里提出了两种证据，表明大鼠单侧纹状体DA耗损并不影响对视觉奖励信号的感觉注意，而是损害了对侧运动行为的开始（尽管不是完成）。这些结果不仅有助于阐明黑质纹状体DA投射的功能，而且还表明该系统的消耗与反应启动过程特异性相关，这可能是帕金森病的根本损伤。
Although Parkinson's disease has traditionally been considered as a motor disorder1,2, there has been much recent interest in the nature and the neural substrates of parkinsonian dementia3,4and cognitive dysfunction4. These disabilities, which can induce visuospatial impairment5and visual ‘neglect’6, may also have a bearing on the controversy about the normal functions of the nigrostriatal dopamine (DA) projection and the basal ganglia2,7–9. The observations that neurones in both substantia nigra and striatum respond to sensory events in terms of neuronal firing10,11or DA release12,13, also suggest a role for striatum in sensorimotor integration. An important behavioural correlate of this integration is the ‘sensorimotor neglect’ syndrome14in animals with unilateral lesions of the nigrostriatal projection who fail to orient to contralateral sensory events. However, this neglect may arise not from contralateral sensory inattention14,15, but from an inability to express this sensory selection via motor output. We present here two lines of evidence that unilateral striatal DA depletion in the rat does not affect sensory attention to visual signals of reward, but rather impairs the initiation (though not the completion) of contralateral motor acts. These results not only help to clarify the function of the nigrostriatal DA projection, but also show that depletion in this system is linked specifically to a process of response initiation, which may be the fundamental impairment in Parkinson's disease.