Cerebrogenic cardiac arrhythmias: Cortical lateralization and clinical significance
Cerebrogenic cardiac arrhythmias: Cortical lateralization and clinical significance
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DOI：
10.1007/s10286-006-0276-0
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发表时间：
2006-02-01
影响因子：
5.8
通讯作者：
Oppenheimer, S
中科院分区：
文献类型：
--
作者：
Oppenheimer, S
大脑可能参与心血管调节已经被承认超过世纪。心律失常可能是由皮质紊乱引起的，这一点还没有得到很好的认识。皮质心脏代表可能是偏侧的，这一点甚至更有争议。最近的证据表明，几个皮质结构，特别是丘脑，在心率和节律的控制。实验模型表明，岛叶病变可能是致炎性的。累积的数据显示，在人类中有类似的损伤效应。在大鼠、猴和人中，交感心血管控制通常表现在右丘脑中，尽管已经证明了明显的岛叶-岛叶连接。心脏交感迷走神经平衡的预防性变化发生在人类中风后，包括左岛叶病变。这一证据表明，在适当的情况下，皮质参与了心血管功能障碍的促进甚至产生。
That the brain may be involved in cardiovascular regulation has been acknowledged for over a century. That cardiac arrhythmias may result from cortical derangement has been less well recognized. That cortical cardiac representation may be lateralized is even more controversial. Recent evidence implicates several cortical structures, especially the insula, in cardiac rate and rhythm control. Experimental models indicate that insular lesions maybe arrhythmogenic. Accumulating data show similar lesion effects in humans. In the rat, monkey and man sympathetic cardiovascular control is generally represented in the right insula, although pronounced insulo-insular connectivity has been demonstrated. Proarrhythmic shifts in cardiac sympathovagal balance occur after human stroke, including left insular lesions. This evidence implicates the cortex in the promotion and even generation of cardiovascular dysfunction under appropriate circumstances.