1,3-Dithianes as Acyl Anion Equivalents in Pd-Catalyzed Asymmetric Allylic Substitution
1,3-Dithianes as Acyl Anion Equivalents in Pd-Catalyzed Asymmetric Allylic Substitution
复制标题
1,3-二噻烷作为 Pd 催化不对称烯丙基取代中的酰基阴离子当量
DOI：
10.1021/acs.orglett.6b03161
复制
发表时间：
2016
期刊：
影响因子：
5.2
通讯作者：
Zhang Wanbin
中科院分区：
文献类型：
--
作者：
Yao Kun;Liu Delong;Yuan Qianjia;Imamoto Tsuneo;Liu Yangang;Zhang Wanbin
以1,3-二硫代烷为酰基阴离子当量的pd催化不对称烯丙基取代反应具有高收率和良好的对映选择性。反应以克为单位进行，相应的烷基化产物可方便地转化为多种生物活性产物。这项工作提供了一种利用亲电羰基化合物作为pd催化的烯丙基取代的亲核物质的替代策略。
A Pd-catalyzed asymmetric allylic substitution with 1,3-dithianes as acyl anion equivalents has been developed in high yields and excellent enantioselectivities. The reaction was performed on a gram scale, and the corresponding alkylated products were conveniently converted into several biologically active products. This work provides an alternative strategy utilizing electrophilic carbonyl compounds as nucleophilic species in a Pd-catalyzed allylic substitution.