Gating of the vertex somatosensory and auditory evoked potential P50 and the correlation to skin conductance orienting response in healthy men
Gating of the vertex somatosensory and auditory evoked potential P50 and the correlation to skin conductance orienting response in healthy men
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DOI：
10.1016/s0165-1781(01)00226-8
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发表时间：
2001-04-15
影响因子：
11.3
通讯作者：
Chen, ACN
中科院分区：
文献类型：
--
作者：
Arnfred, SM;Eder, DN;Chen, ACN
听觉诱发电位（AEP）P50门控缺陷支持精神分裂症信息加工缺陷理论。中潜伏期诱发电位（EP）门控在躯体感觉和听觉模态之间的关系还没有一起研究过。在精神分裂症中，我们可以预期加工缺陷会对多种模式产生作用。我们研究了正中神经体感EP（SEP）的门控配对刺激后相同的AEP P50门控范式，使用刺激间间期（ISI）为500，750和1000 ms和门控的相关性皮肤电导定向反应（SCOR）在20名健康男性。我们测量了中潜伏期顶点成分（SEP：P50，N65，P85和N100; AEP：P30，N45，P50和N80）。门控在ISI 500 ms时最明显，其中SEP P50和N100门控分别为0.59和0.37，而AEP中P30门控为0.61，P50门控为0.33，N80门控为0.45。两种模式的重复效应不相关。AEP P50门控与皮肤电导水平（SCL）相关。两种模式中记录重复对中潜伏期EP的影响的组合可以提供一种方法来调查精神分裂症的信息加工缺陷是否是跨模式的。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
A defect in auditory evoked potential (AEP) P50 gating supports the theory of information-processing deficits in schizophrenia. The relationship between gating of the mid-latency evoked potentials (EP) in the somatosensory and the auditory modalities has not been studied together before. In schizophrenia, we might expect the processing deficits to act on multiple modalities. We have examined the gating of median nerve somatosensory EP (SEP) following paired stimulation identical to the AEP P50 gating paradigm using interstimulus intervals (ISI) of 500, 750 and 1000 ms and the correlation of gating to the skin conductance orienting response (SCOR) in 20 healthy men. We measured mid-latency vertex components (SEP: P50, N65, P85 and N100; AEP: P30, N45, P50 and N80). The gating was most pronounced at ISI 500 ms where the SEP P50 and N100 gating were 0.59 and 0.37, respectively, as compared to a gating of 0.61 in P30, 0.33 in P50 and 0.45 in N80 in the AEP. Repetition effects in the two modalities were not correlated. AEP P50 gating was correlated to skin conductance level (SCL). The combination of recording repetition effects on the mid-latency EP in two modalities could provide a method for investigating if deficits of information processing in schizophrenia are cross-modal. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.