The effects of the DASH dietary pattern on clinical outcomes and quality of life in adults with uncontrolled asthma: Design and methods of the ALOHA Trial.
The effects of the DASH dietary pattern on clinical outcomes and quality of life in adults with uncontrolled asthma: Design and methods of the ALOHA Trial.
复制标题
DASH 饮食模式对哮喘未受控制的成人临床结果和生活质量的影响：ALOHA 试验的设计和方法。
DOI：
10.1016/j.cct.2023.107274
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发表时间：
2023
影响因子：
2.2
通讯作者：
Ma,J
中科院分区：
文献类型：
--
作者：
Nyenhuis,SM;Dixon,A;Wood,L;Lv,N;Wittels,N;Ronneberg,CR;Xiao,L;Dosala,S;Marroquin,A;Barve,A;Harmon,W;Poynter,M;Parikh,A;CamargoJr,CA;Appel,L;Ma,J
背景不良的饮食质量是哮喘患病率增加和哮喘控制不良的重要危险因素。为了解决成年哮喘患者是否可以从遵循健康饮食中获益的问题，本试验将测试行为干预的有效性和作用机制，该行为干预促进了不受控制的哮喘患者中钠减少的饮食方式来停止高血压（DASH）饮食模式。将320名接受标准控制剂治疗的哮喘未得到控制的种族/民族和社会经济多样化成人随机分配至对照组或干预组，并在基线、3、6和12个月时进行评估。对照组和干预组参与者将接受有关肺部健康、哮喘和其他一般健康主题的教育;此外，干预组将接受为期12个月的DASH行为咨询。主要假设是，与仅接受教育的对照组相比，DASH行为干预将导致更多的参与者在12个月时哮喘特异性生活质量的临床重要改善（应答者）最小。次要假设将测试对其他哮喘的干预效果（例如，哮喘控制，肺功能）和非哮喘结果（例如，生活质量）。此外，治疗性（例如，短链脂肪酸，细胞因子）和营养生物标志物（例如，饮食炎症指数，类胡萝卜素）将被评估，以了解干预效果的机制。ConclusionThis trial can substantially advance asthma care by providing rigid evidence on the benefits of a behavioral dietary intervention and mechanistic insights into the role of diet quality in asthma.clinicaltrials.gov #：NCT 05251402
BackgroundPoor diet quality is an important risk factor for increased asthma prevalence and poor asthma control. To address the question of whether adults with asthma can benefit from following a healthy diet, this trial will test the efficacy and mechanisms of action of a behavioral intervention promoting the Dietary Approaches to Stop Hypertension (DASH) dietary pattern with sodium reduction among patients with uncontrolled asthma.MethodsIn this 2-arm randomized clinical trial, 320 racially/ethnically and socioeconomically diverse adults with uncontrolled asthma on standard controller therapy will be randomized to either a control or an intervention group and assessed at baseline, 3, 6 and 12 months. Control and intervention participants will receive education on lung health, asthma, and other general health topics; additionally, the intervention group will receive DASH behavioral counseling over 12 months. The primary hypothesis is that the DASH behavioral intervention, compared with the education-only control, will lead to significantly more participants with minimum clinically important improvement (responders) in asthma-specific quality of life at 12 months. Secondary hypotheses will test the intervention effects on other asthma (e.g., asthma control, lung function) and non-asthma outcomes (e.g., quality of life). Additionally, therapeutic (e.g., short chain fatty acids, cytokines) and nutritional biomarkers (e.g., dietary inflammatory index, carotenoids) will be assessed to understand the mechanisms of the intervention effect.ConclusionThis trial can substantially advance asthma care by providing rigorous evidence on the benefits of a behavioral dietary intervention and mechanistic insights into the role of diet quality in asthma.clinicaltrials.gov #: NCT05251402