Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters
Tumour-cell migration, invasion, and metastasis: navigation by neurotransmitters
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DOI：
10.1016/s1470-2045(04)01431-7
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发表时间：
2004-04-01
期刊：
影响因子：
51.1
通讯作者：
Zaenker, KS
中科院分区：
文献类型：
--
作者：
Entschladen, F;Drell, TL;Zaenker, KS
癌症最初是一种局部疾病，如果及早发现，通常可以通过切除原发肿瘤来成功治疗。恶性进展是肿瘤细胞侵入周围组织，导致远处转移。由于肿瘤细胞的主动迁移是肿瘤细胞侵袭和转移的先决条件，因此肿瘤生物学的一个紧迫目标是阐明调节这些细胞迁移活性的因素。最突出的调节因子是蛇纹石受体的配体，例如趋化因子和神经递质。许多类型的神经递质受体在肿瘤细胞上表达，支持了心理社会因素参与癌症进展的理论。了解这些受体如何调节迁移以及特定受体拮抗剂的可用性可以为肿瘤细胞迁移和转移发展的化学预防开辟新途径。
Cancer starts as a localised disease, which, if detected early, can often be treated successfully by removal of the primary tumour. A pernicious progression is the invasion of tumour cells into surrounding tissues, resulting in development of distant metastases. Because active migration of tumour cells is a prerequisite for tumour-cell invasion and metastasis, a pressing goal in tumour biology has been the elucidation of factors regulating the migratory activity of these cells. The most prominent regulatory factors are ligands to serpentine receptors-eg, chemokines and neurotransmitters. Many types of neurotransmitter receptors are expressed on tumour cells, supporting the theory that psychosocial factors are involved in the progression of cancer. Understanding how such receptors regulate migration and the availability of specific receptor antagonists could open up new avenues for chemoprevention of tumour-cell migration and metastatic development.