Conceptual apraxia in Alzheimer's disease.
Conceptual apraxia in Alzheimer's disease.
复制标题
阿尔茨海默氏病的概念失用症。
DOI：
10.1093/brain/115.4.1061
复制
发表时间：
1992
期刊：
影响因子：
--
通讯作者：
Heilman,KM
中科院分区：
文献类型：
--
作者：
Ochipa,C;Rothi,LJ;Heilman,KM
实践的理论模型有两个主要组成部分，一个是包含工具使用知识和机械知识的实践概念系统，另一个是包含编程熟练动作所需信息的实践生产系统。因为阿尔茨海默病患者可能有中枢概念系统的损伤，我们想知道他们是否有概念性失用症，通过测试他们对与工具使用相关的动作类型的知识，他们将工具与接受其动作的物体联系起来的能力，他们理解问题的机械本质的能力以及工具可能提供的机械优势的能力。我们研究了32名可能患有阿尔茨海默病的受试者和32名对照组，通过检查工具-动作关系和工具-物体关联。我们通过让受试者选择替代工具来测试机械知识，并通过开发新工具来解决机械难题。阿尔茨海默氏症组根据是否存在意识形态运动失用症和词汇语义缺陷被细分为四组。结果表明，四组阿尔茨海默氏症患者在概念性失用症的某些方面与正常对照有所不同，这表明阿尔茨海默氏症患者确实存在实践概念系统的障碍，而该系统的损伤与语言障碍或观念运动失用症没有直接关系。
Theoretical models of praxis have two major components, a praxis conceptual system that includes knowledge of tool use and mechanical knowledge and a praxis production system that includes the information needed to program skilled motor acts. Because patients with Alzheimer's disease may have an impairment of the central conceptual system, we wanted to learn if they had a conceptual apraxia by testing their knowledge of the type of actions associated with tool use, their ability to associate tools with objects that receive their action, their ability to understand the mechanical nature of problems and the mechanical advantages tools may afford.We studied 32 subjects with probable Alzheimer's disease and 32 controls by examining tool-action relationships and tool-object associations We tested mechanical knowledge by having subjects select alternative tools and solve mechanical puzzles by developing new tools. The Alzheimer's group was subdivided into four groups based on the presence or absence of ideomotor apraxia and a lexical-semantic deficit.Results indicated that each of the four Alzheimer's groups differed from normal controls on at least some measures of conceptual apraxia, suggesting that Alzheimer's patients do have a disturbance of the praxis conceptual system and that impairment of this system is not directly related to language impairment or ideomotor apraxia.