RISK-FACTORS IN TRANSMISSION OF BRUCELLOSIS FROM ANIMALS TO HUMANS IN SAUDI-ARABIA
RISK-FACTORS IN TRANSMISSION OF BRUCELLOSIS FROM ANIMALS TO HUMANS IN SAUDI-ARABIA
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DOI：
10.1016/0035-9203(92)90575-w
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发表时间：
1992-03-01
影响因子：
2.2
通讯作者：
COOPER, CW
中科院分区：
文献类型：
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作者：
COOPER, CW
在沙特阿拉伯开展了一项病例对照研究，首次确定布鲁氏菌病动物向人类传播的具体病原学。病例包括在沙特阿拉伯中部利雅得医院方案初级保健诊所就诊的所有布鲁氏菌病患者。同时从同一诊所就诊的不相关问题患者中选择单独匹配的对照样本。病例和对照者回答了一份包含48个项目的关于接触已知布鲁氏菌病危险因素的问卷。研究发现，与直接接触动物相比，与动物间接接触（食用未经巴氏消毒的乳制品）的风险最大。当考虑到特定的动物产品时，最大的风险与牛奶和拉班（酪乳）有关，而不是奶酪或未煮熟的肝脏。当考虑到特定的动物物种时，风险最大的是来自绵羊和山羊的产品，而不是骆驼和牛的产品。当考虑到与动物的直接接触时，研究发现与协助动物分娩相关的风险非常高，但与其他直接（未指明的）动物接触没有显著风险相关。
A case-control study was undertaken to determine for the first time the specific aetiology of animal to human transmission of brucellosis in Saudi Arabia. Cases consisted of all patients with brucellosis attending the primary care clinic of the Riyadh Al-Kharj Hospital programme in central Saudi Arabia. A sample of individually matched controls was selected concurrently from patients attending the same clinic for unrelated problems. Cases and controls responded to a 48 item questionnaire on exposure to established risk factors for brucellosis. Greatest risk was found to be associated with indirect contact with animals (the consumption of unpasteurized dairy products), as opposed to direct contact with animals. When specific animal products were considered, greatest risk was associated with the consumption of milk and laban (buttermilk), as opposed to cheese or uncooked liver. When specific animal species were considered, greatest risk was associated with products derived from sheep and goats as opposed to camels and cattle. When direct contact with animals was considered, the study found a very high risk associated with assisting in animal parturition, but no significant risk associated with other direct (unspecified) animal contact.