Patterns of cognitive decline in aged rhesus monkeys
Patterns of cognitive decline in aged rhesus monkeys
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DOI：
10.1016/s0166-4328(96)02256-5
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发表时间：
1997-08-01
影响因子：
2.7
通讯作者：
Killiany, RJ
中科院分区：
文献类型：
--
作者：
Herndon, JG;Moss, MB;Killiany, RJ
尽管在非人灵长类动物模型中已明确认知能力下降是衰老的结果，但尚未描述特定年龄范围的损害的患病率或频率。本研究的第一个目的是通过比较早期（19-23岁）、高龄（24-28岁）和高龄（29岁以上）猴与年轻成年猴（< 15岁）的表现，估计6项认知表现测试中每项测试的认知障碍患病率。第二个目标是得出一个单一的认知表现的总体衡量标准，以帮助对我们老年猴子的行为功能进行分类。因此，我们获得了这些年龄组的六个行为测量指标：（1）延迟非匹配样本任务（DNMS）的获得，（2）延迟120秒的DNMS的执行，（3）延迟再认广度测试（DRST）的空间条件，（4）DRST的颜色条件，（5）空间反转学习，（6）延迟再认广度测试（DRST）的空间条件。（6）对象反转学习。早期年龄的猴子显示的患病率的损害显着大于零的所有任务，除了DRST颜色。在这个年龄组中，在测量空间记忆（DRST）的任务中观察到最高的损伤患病率。在高龄和最高龄的猴子中，观察到DNMS采集，DRST颜色和空间反转学习任务的显著趋势是逐渐升高的损伤率。通过主成分分析（PCA）的线性变换的标准化分数的六个认知测试。第一个主成分分析（PCA 1）包括30只猴子的数据，所有六个措施的数据，并产生了一个复合措施，随着年龄的增长线性下降（r = -0.74）。对53只猴子的数据进行第二次PCA（PCA 2），其中有三个测试评分（DNMS-采集、DNMS-120秒延迟和DRST-空间条件）。从该分析得出的综合评分与PCA 1的综合评分高度相关（r = 0.93），这表明仅基于三项测试的评分可以提供对全局认知能力的充分分类。(C)1997年Elsevier Science B.V.
Although cognitive decline has been well established as a consequence of aging in non-human primate models, the prevalence or frequency of impairment for specific age ranges has not been described. The first aim of this study was to estimate prevalence of cognitive impairment on each of the six tests of cognitive performance by comparing the performance of early-aged (19-23 years old), advanced-aged (24-28 yeras old), and oldest-aged (29 + years old) monkeys to that of young adults ( < 15 years old). The second aim was to derive a single overall measure of cognitive performance to help classify behavioral function in our aged monkeys. Accordingly, we obtained performance measures for these age groups on six behavioral measures: (1) acquisition of the delayed non-matching-to-sample task (DNMS); (2) performance of the DNMS with a delay of 120 sec; (3) the spatial condition of the delayed recognition span test (DRST); (4) the color condition of the DRST; (5) spatial reversal learning; and (6) object reversal learning. Early-aged monkeys displayed prevalence rates of impairment significantly greater than zero on all tasks except the DRST-color. The highest prevalence of impairment was observed in this age group in a task measuring spatial memory (DRST). Significant trends toward progressively higher impairment rates in advanced-aged and oldest-aged monkeys were observed for DNMS-acquisition, DRST-color and spatial reversal learning tasks. A linear transformation of standardized scores on the six cognitive tests was derived by means of principal components analysis (PCA). The first PCA (PCA1) included data from 30 monkeys with available data on all six measures, and yielded a composite measure which declined linearly with increasing age (r = -0.74). A second PCA (PCA2) was performed on data from 53 monkeys for which three test scores (DNMS-acquisition, DNMS-120s delay, and DRST-spatial condition) were available. The composite score derived from this analysis was highly correlated (r = 0.93) with the composite score from PCA1, suggesting that a score based on only three tests may provide an adequate classification of global cognitive ability. (C) 1997 Elsevier Science B.V.