Variability of respiratory mechanics during sleep in overweight and obese subjects with and without asthma.
Variability of respiratory mechanics during sleep in overweight and obese subjects with and without asthma.
复制标题
在有和没有哮喘的超重和肥胖受试者中睡眠期间的呼吸力学变异性。
DOI：
10.1016/j.resp.2013.02.026
复制
发表时间：
2013-05-01
影响因子：
2.3
通讯作者：
Malhotra, A.
中科院分区：
文献类型：
--
作者：
Campana, L. M.;Owens, R. L.;Butler, J. P.;Suki, B.;Malhotra, A.
呼吸的变化可以提供关于疾病状态的信息。我们试图描述健康人和哮喘患者通气和阻力的变化，以确定睡眠和双水平气道正压通气（BPAP）如何改变呼吸控制。超重和肥胖的受试者，并没有哮喘进行了研究，在睡眠中的基线和BPAP，同时测量呼吸系统阻力（Rrs）连续。确定清醒、NREM和REM睡眠的稳定期（> 20分钟），并计算呼吸参数的相关性度量，包括变异系数（CV）。Rrs的变异性还在睡眠期间的短时间尺度（20次呼吸）内进行了表征，并定义为“导致觉醒”或“不导致觉醒”。分析了10名对照组和10名哮喘受试者的数据。与基线相比，哮喘患者Rrs的CV在基线时降低（p<0.001），BPAP患者Rrs的CV在基线时降低（p<0.001）。呼吸参数存在长时间尺度的相关性，但相关程度从清醒到睡眠逐渐降低（P<0.05）。在基线时，Rrs的方差和CV在从睡眠中唤醒之前增加;然而，在BPAP期间，CV在唤醒之前降低而没有增加。基线时，哮喘患者的抵抗力更大，但变异性较小。BPAP降低了阻力和总体变异性。我们的结论是，BPAP诱导的变异性降低可能表明，哮喘患者更有可能保持在低阻力状态，低阻力变异性可能会减少从睡眠中觉醒。
Variability of respiration may provide information regarding disease states. We sought to characterize variability of ventilation and resistance in healthy and asthma, to determine how respiratory control may be altered in sleep and with bi-level positive airway pressure (BPAP). Overweight and obese subjects with and without asthma were studied during sleep at baseline and with BPAP, while measuring respiratory system resistance (Rrs) continuously. Stable periods (>20min) of wake, NREM, and REM sleep were identified and correlation metrics of respiratory parameters were calculated, including coefficient of variation (CV). Variability of Rrs was also characterized over short time scales (20 breaths) during sleep and defined as either “leading to arousal” or “not leading to arousal”. Data from 10 control and 10 subjects with asthma were analyzed. CV of Rrs was decreased in asthma at baseline (p<0.001) and decreased on BPAP as compared to baseline (p<0.001). Long time scale correlations were found in respiratory parameters, but the degree of correlations was decreased from wake to sleep (p<0.05). The variance and CV of Rrs was increased preceding an arousal from sleep at baseline; however, during BPAP, the CV was decreased and was not increased preceding arousals. At baseline, resistance was greater in those with asthma, but variability was smaller. BPAP reduced both resistance and overall variability. We conclude that the BPAP-induced decrease in variability may indicate that those with asthma are more likely to remain in a low resistance state, and that low resistance variability may reduce arousals from sleep.
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影响因子：
39.3
作者：
Bauer A;Barthel P;Schneider R;Ulm K;Müller A;Joeinig A;Stich R;Kiviniemi A;Hnatkova K;Huikuri H;Schömig A;Malik M;Schmidt G
通讯作者：
Schmidt G
影响因子：
4.3
作者：
Ciftci, TU;Ciftci, B;Turktas, H
通讯作者：
Turktas, H
影响因子：
5.6
作者：
Rostig, S;Kantelhardt, JW;Jerrentrup, A
通讯作者：
Jerrentrup, A
DOI：
10.1164/rccm.200202-152pp
发表时间：
2002-07-15
影响因子：
24.7
作者：
Suki, B
通讯作者：
Suki, B
DOI：
10.1164/rccm.2201018
发表时间：
2002-05-01
影响因子：
24.7
作者：
Brack, T;Jubran, A;Tobin, MJ
通讯作者：
Tobin, MJ