The changing pattern of bloodstream infections associated with the rise in HIV prevalence in northeastern Thailand
The changing pattern of bloodstream infections associated with the rise in HIV prevalence in northeastern Thailand
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DOI：
10.1016/j.trstmh.2004.01.011
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发表时间：
2004-11-01
影响因子：
2.2
通讯作者：
White, NJ
中科院分区：
文献类型：
--
作者：
Chierakul, W;Rajanuwong, A;White, NJ
1989年至1998年，在泰国东北部乌汶拉查塔尼的一家大型地区医院进行了一项血液感染调查，当时正值艾滋病毒流行的开始。金黄色葡萄球菌、大肠埃希菌、克雷伯氏菌/肠杆菌和铜绿假单胞菌的发病率保持不变，而假杆菌伯克氏菌、非伤寒沙门氏菌、新型隐球菌、马尼菲青霉菌和肺炎链球菌引起的感染均有所上升。假性伯克霍尔德菌感染与HIV无关，而其他感染与HIV直接相关。D组非伤寒沙门氏菌血液感染（主要是肠炎沙门氏菌）的增加与HIV血清预防的增加一致，并且先于其他HIV相关感染的增加。其他非伤寒沙门氏菌菌血症在D组感染增加两年后增加，侵袭性酵母菌感染在四年后增加，与艾滋病的增加相一致。D组非伤寒沙门氏菌血液感染的增加是艾滋病即将上升的早期预警信号。(C) 2004年皇家热带医学与卫生学会。Elsevier Ltd.出版。版权所有。
A survey of bloodstream infections was conducted in the large regional hospital in Ubon Ratchatani, northeastern Thailand between 1989 and 1998, during the onset of the HIV epidemic. The incidence of Staphylococcus Aureus, Escherichia coli, Klebsiella/Enterobacter and Pseudomonas aeruginosa bacteraemias remained constant whereas infections caused by Burkholderia pseudomallei, non-typhoid Salmonellae, Cryptococcus neoformans, Penicillum marneffei and to a lesser extent Streptococcus pneumoniae all rose. Burkholderia pseudomallei infections were unrelated to HIV, whereas the other infections were associated directly with HIV. Group D non-typhoid Salmonellae bloodstream infections (mainly Salmonella enteritidis) rose coincident with the increase in HIV seroprevatence, and preceded the increase in the other HIV-associated infections. Other non-typhoid Salmonella bacteraemias increased two years after the rise in group D infections, and invasive yeast infections increased four years later, coincident with the increase in AIDS. Increasing Group D non-typhoid Salmonella bloodstream infections are an early warning signal of an impending rise in AIDS. (C) 2004 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.