RELATIONSHIPS BETWEEN ORIENTATION-PREFERENCE PINWHEELS, CYTOCHROME-OXIDASE BLOBS, AND OCULAR-DOMINANCE COLUMNS IN PRIMATE STRIATE CORTEX
RELATIONSHIPS BETWEEN ORIENTATION-PREFERENCE PINWHEELS, CYTOCHROME-OXIDASE BLOBS, AND OCULAR-DOMINANCE COLUMNS IN PRIMATE STRIATE CORTEX
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DOI：
10.1073/pnas.89.24.11905
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发表时间：
1992-12-15
影响因子：
11.1
通讯作者：
GRINVALD, A
中科院分区：
文献类型：
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作者：
BARTFELD, E;GRINVALD, A
在猕猴的一级视觉皮层中探索了细胞色素氧化酶斑点，眼义列和ISO定向域，子系统的子系统之间的关系。获得了这三个子系统的高分辨率图。基于活动依赖性内在信号的光学成像表明，定向偏好的最突出的组织特征是径向排列，形成了围绕奇异点的风车样结构。这些风车中有80％以上以眼义柱的中线为中心。相邻的针齿的同级方向轮廓以大约直接的角度越过眼部占主导地位的边界。相同或相反方向的风车彼此平稳连接。平均而言，所有方向平均表示。在完全相同的皮质区域中，还使用细胞色素氧化酶的组织学绘制了被认为与颜色加工有关的细胞色素氧化酶斑点。像风车的中心一样，斑点的中心也位于眼义柱的中线。但是，Pinwwheels的中心与Blobs的中心不一致。这两个子系统在空间上是独立的。经常发现“超柱”模块，每个模块都在两个相邻的互补眼和几个斑点的相邻列中的两个完整的风车，但似乎并不是皮质组织的主要单位。提出了一种替代高柱的替代方法。
The relationships between cytochrome oxidase blobs, ocular-dominance columns, and iso-orientation domains, subsystems underlying visual perception, were explored in primary visual cortex of macaque monkey. High-resolution maps of these three subsystems were acquired. Optical imaging based on activity-dependent intrinsic signals revealed that the most prominent organizational feature of orientation preference was a radial arrangement, forming a pinwheel-like structure surrounding a singularity point. More than 80% of these pinwheels were centered along the midline of ocular-dominance columns. The iso-orientation contours of adjacent pinwheels crossed borders of ocular-dominance columns at approximately right angles. Pinwheels with the same or opposite directions of orientation-preference change were smoothly connected with each other. On the average, all orientations were equally represented. In exactly the same cortical area, the cytochrome oxidase blobs, thought to be involved in color processing, were also mapped, using cytochrome oxidase histology. Like the centers of pinwheels, the centers of blobs also lie along the midline of ocular-dominance columns. However, the centers of pinwwheels did not coincide with the centers of blobs; these two subsystems are spatially independent. "Hypercolumn" modules, each including two complete pinwheels in two adjacent columns of complementary ocularity, as well as portions of a few blobs, were frequently found but did not seem to be the primary unit of cortical organization. An alternative to hypercolumns is proposed.