Clusterin Expression Correlates With Stage and Presence of Large Cells in Mycosis Fungoides
Clusterin Expression Correlates With Stage and Presence of Large Cells in Mycosis Fungoides
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DOI：
10.1309/ajcph43zdvlsosnb
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发表时间：
2009-04-01
影响因子：
3.5
通讯作者：
Prieto, Victor G.
中科院分区：
文献类型：
--
作者：
Chandra, Pranil;Plaza, Jose A.;Prieto, Victor G.
Clusterin expression is common in systemic and cutaneous anaplastic large cell lymphoma (ALCL). Mycosis fungoides (MF) in large cell transformation can resemble ALCL. In this study, we immunohistochemically assessed for clusterin in 97 skin biopsy specimens, including 70 MF eases and 27 other cutaneous neoplasms including ALCL, peripheral T-cell lymphoma unspecified (PTCL), and lymphomatoid papulosis (LyP). Clustel-in was positive in 36 (51%) of 70 cases of MF and correlated with clinical stage in 68 cases: 3 of 21 stage I, II of 20 stage II, and 23 of 27 stage III/IV. Clusterin expression also correlated with type of skin lesion (3119 patch, 13128 plaque, and 20123 tumor/erythroderma) and number of large cells (6130 small cell, 12118 with increased large cells, and 18122 with large cell transformation). Clusterin expression was not specific MF as it also was positive in 3 of 3 cases of LyP, 2 of 2 systemic ALCL cases involving skin, 7 of 16 cutaneous ALCLs, and 1 of 6 PTCLs.
