SUBSTANCE-P AS A BARORECEPTOR AND CHEMORECEPTOR AFFERENT NEUROTRANSMITTER - IMMUNO-CYTOCHEMICAL AND NEUROCHEMICAL EVIDENCE IN THE RAT
SUBSTANCE-P AS A BARORECEPTOR AND CHEMORECEPTOR AFFERENT NEUROTRANSMITTER - IMMUNO-CYTOCHEMICAL AND NEUROCHEMICAL EVIDENCE IN THE RAT
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DOI：
10.1016/0196-9781(80)90027-3
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发表时间：
1980-01-01
期刊：
影响因子：
3
通讯作者：
JACOBOWITZ, DM
中科院分区：
文献类型：
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作者：
HELKE, CJ;ODONOHUE, TL;JACOBOWITZ, DM
用放射免疫法定量分析了sp样免疫反应性（SP-I）在不同水平的孤束核（NTS），即这些传入神经的终止部位，同时用免疫细胞化学方法研究了周围神经通路不同部位含有sp的传入神经元。NTS含有大量的sp - 1，单侧切除结节神经节减少了NTS中已知接收迷走神经传入的部分sp - 1的含量。在主动脉弓外膜、颈动脉窦区、迷走神经和结节神经节的离散纤维中可见sp - 1。这些在大鼠身上的结果与先前在猫身上的研究一致，并进一步证明SP包含在气压和化学受体传入神经中。
SP-like immunoreactivity (SP-I) was analyzed quantitatively by radioimmunoassay in various levels of the nucleus tractus solitarius (NTS), the site of termination of these afferents while SP-containing afferent neurons were studied in various portions of the peripheral pathways by immunocytochemistry. The NTS contained significant amounts of SP-I and that unilateral removal of the nodose ganglia reduces the SP-I content of those portions of the NTS known to receive vagal afferents. SP-I was visualized in discrete fibers in the tunica adventitia of the aortic arch and carotid sinus regions, the vagus nerve and nodose ganglia. These results in the rat are consistent with previous studies in the cat and provide further evidence that SP is contained within baro- and chemoreceptor afferent nerves.