Increased erythropoietin synthesis in patients with COLD or left heart failure is related to alterations in renal haemodynamics
Increased erythropoietin synthesis in patients with COLD or left heart failure is related to alterations in renal haemodynamics
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感冒或左心衰竭患者促红细胞生成素合成增加与肾血流动力学的改变有关
DOI：
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发表时间：
2001
影响因子：
5.5
通讯作者：
Serge Adnot
中科院分区：
文献类型：
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作者：
I. Pham;P. Andrivet;S. Sediame;Christian Defouilloy;S. Moutéreau;V. Wirquin;Christos Chouaid;Bruno Housset;Serge Adnot
慢性阻塞性肺疾病（COLD）或充血性左心衰（CLHF）患者肾脏控制促红细胞生成素（EPO）合成的机制仍不完全清楚。在这些疾病中，肾功能不全是由于肾血流量（RBF）减少而发生的。由于肾脏血流动力学的改变可能影响EPO合成和红细胞生成，我们研究了COLD或CLHF患者肾功能和血浆EPO合成之间的潜在关系。
The mechanisms controlling erythropoietin (EPO) synthesis by the kidney in patients with chronic obstructive lung disease (COLD) or congestive left heart failure (CLHF) remain incompletely understood. Renal dysfunction occurs as a consequence of decreased renal blood flow (RBF) in these diseases. Because alterations in renal haemodynamics may affect EPO synthesis and red blood cell production, we investigated the potential relationships between renal function and plasma EPO synthesis in patients with COLD or CLHF.