Characterization of the relationship between intracranial pressure and electroencephalographic monitoring in burst-suppressed patients.
Characterization of the relationship between intracranial pressure and electroencephalographic monitoring in burst-suppressed patients.
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DOI：
10.1007/s12028-014-0059-8
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发表时间：
2015-04
影响因子：
3.5
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Connolly M;Vespa P;Pouratian N;Gonzalez NR;Hu X
为了刻画脑电和颅内压之间的关系，我们从突发抑制患者中同时获得了脑电和颅内压的数据，并用脑电突发对两者进行了分割。将脑电节段分为增减节段和峰谷节段，探讨颅内压变化与脑电持续时间的关系。通过对所有节段在猝发起始点的时间排列进行平均，得到广义的ICP响应。血管扩张指数(VDI)是从颅内压脉冲波形中得出的，并按滑动区间计算，以研究猝发后脑血管的变化。来自两名患者的数据包含309个脉冲串。246个ICP节段最初增加，其中154个节段达到峰值。63个颅内压节段减少，0个节段达谷值。颅内压的变化(0.54±0.85 mm Hg)与发作持续时间显著相关(p<；0.001)。颅内压节段的特征显示峰值出现在8.1s，并在14.7s回到基线。增加节段的VDI值显著升高(中位数0.56，IQR0.31，P<；0.001)，并与心搏持续时间相关(P<；0.001)。脑电爆发后颅内压和脉搏波形的变化表明，这些信号可能与神经血管耦合有关。颅内压和脑电之间的生理关系的存在可能为研究急性脑损伤患者的神经血管偶联提供了可能。
To characterize the relationship between ICP and EEG Simultaneous ICP and EEG data were obtained from burst-suppressed patients and segmented by EEG bursts. Segments were categorized as increasing/decreasing and peak/valley to investigate relationship between ICP changes and EEG burst duration. A generalized ICP response was obtained by averaging all segments time-aligned at burst onsets. A vasodilatation index (VDI) was derived from the ICP pulse waveform and calculated on a sliding interval to investigate cerebrovascular changes post-burst. Data from two patients contained 309 bursts. 246 ICP segments initially increased, of which 154 peaked. 63 ICP segments decreased, and zero reached a valley. The change in ICP (0.54±0.85mmHg) was significantly correlated with the burst duration (p<0.001). Characterization of the ICP segments showed a peak at 8.1s and a return to baseline at 14.7s. The VDI for increasing segments was significantly elevated (median 0.56, IQR 0.31, p<0.001) and correlated with burst duration (p<0.001). Changes in the ICP and pulse-waveform shape after EEG burst suggest that these signals can be related within the context of neurovascular coupling. Existence of a physiological relationship between ICP and EEG may allow the study of neurovascular coupling in acute brain injury patients.
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DOI：
10.1109/tbme.2008.2008636
发表时间：
2009-03
期刊：
IEEE transactions on bio-medical engineering
影响因子：
--
作者：
Hu X;Xu P;Scalzo F;Vespa P;Bergsneider M
通讯作者：
Bergsneider M
影响因子：
1.5
作者：
Koide M;Sukhotinsky I;Ayata C;Wellman GC
通讯作者：
Wellman GC
影响因子：
3.5
作者：
Asgari, Shadnaz;Bergsneider, Marvin;Hamilton, Robert;Vespa, Paul;Hu, Xiao
通讯作者：
Hu, Xiao
影响因子：
4.1
作者：
Vespa, PM;Nuwer, MR;Becker, DP
通讯作者：
Becker, DP
影响因子：
6.3
作者：
Shin, Hwa Kyoung;Dunn, Andrew K.;Ayata, Cenk
通讯作者：
Ayata, Cenk