Hyperpolarized 3He MR lung ventilation imaging in asthmatics:: Preliminary findings
Hyperpolarized 3He MR lung ventilation imaging in asthmatics:: Preliminary findings
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DOI：
10.1002/jmri.1054
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发表时间：
2001-03-01
影响因子：
4.4
通讯作者：
Brookeman, JR
中科院分区：
文献类型：
--
作者：
Altes, TA;Powers, PL;Brookeman, JR
哮喘是一种以慢性炎症和可逆性小气道阻塞为特征的疾病，导致肺通气受损。超极化He-3磁共振（MR）肺成像是一种提供肺通气详细图像的新技术。对10例哮喘患者和10例健康人进行超偏振He-3肺显像。7名哮喘患者有分布在整个肺部的通气缺陷，而正常人没有。在两例呼吸功能异常的有症状的哮喘患者中，这些通气缺陷更多、更大。随着时间的推移研究通风缺陷表明在30-60分钟内外观没有变化。一名哮喘患者在三周内接受了两次研究，并在此期间出现了通气缺陷。同一受试者在支气管扩张剂治疗前后进行了研究，治疗后所有通气缺陷都消失了。超偏振He-3肺显像可以发现哮喘特征的小的、可逆的通气缺陷。可视化肺通气的能力提供了一种评估哮喘患者及其对治疗反应的直接方法。(C) 2001 Wiley-Liss, Inc。
Asthma Is a disease characterized by chronic inflammation and reversible obstruction of the small airways resulting in impaired pulmonary ventilation. Hyperpolarized He-3 magnetic resonance (MR) lung imaging is a new technology that provides a detailed image of lung ventilation. Hyperpolarized He-3 lung imaging was performed In 10 asthmatics and 10 healthy subjects. Seven asthmatics had ventilation defects distributed throughout the lungs compared with none of the normal subjects. These ventilation defects were more numerous and larger in the two symptomatic asthmatics who had abnormal spirometry. Ventilation defects studied over time demonstrated no change in appearance over 30-60 minutes. One asthmatic subject was studied twice in a three-week period and had ventilation defects which resolved and appeared In that time. This same subject was studied before and after bronchodilator therapy, and all ventilation defects resolved after therapy. Hyperpolarized He-3 lung imaging can detect the small, reversible ventilation defects that characterize asthma. The ability to visualize lung ventilation offers a direct method of assessing asthmatics and their response to therapy. (C) 2001 Wiley-Liss, Inc.