Analysis of TBX18 expression in chick embryos
Analysis of TBX18 expression in chick embryos
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DOI：
10.1007/s00427-004-0415-3
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发表时间：
2004-08-01
影响因子：
2.4
通讯作者：
Kispert, A
中科院分区：
文献类型：
--
作者：
Haenig, B;Kispert, A
T-box基因编码转录因子，控制脊椎动物胚胎中不同组织和器官的发育。在这里，我们报告了TBX18基因在雏鸡发育过程中的表达。TBX18在预期和确定的体节的前半部分以及未分段的中轴中胚层的颅骨区域都有表达。在胚泡发育前的中胚层中表达水平较高，而在新形成的体节中表达水平降低。这与小鼠不同，在小鼠中轴旁中胚层有统一的表达。TBX18在心外膜浆膜和心外膜中的表达也很明显。其他表达部位包括生殖器脊和发育中的肢芽。
T-box genes encode transcription factors that control the development of diverse tissues and organs in vertebrate embryos. Here, we report the expression of the TBX18 gene during chick development. TBX18 expression is found in anterior halves of prospective and definitive somites as well as in the unsegmented cranial region of the paraxial mesoderm. Expression levels are high in the presomitic mesoderm but decrease in newly formed somites. This is in contrast to the mouse where uniform expression has been reported in the paraxial mesoderm. TBX18 expression is also prominent in the proepicardial serosa and in the epicardium of the heart. Other sites of expression include the genital ridge and the developing limb buds.