Alterations in coxsackievirus and adenovirus receptor confer susceptibility to ventricular arrhythmia with an ischemic event.
Alterations in coxsackievirus and adenovirus receptor confer susceptibility to ventricular arrhythmia with an ischemic event.
复制标题
柯萨奇病毒和腺病毒受体的改变导致对伴有缺血事件的室性心律失常的易感性。
DOI：
10.1016/j.jacc.2013.12.001
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发表时间：
2013
影响因子：
24
通讯作者：
Fukumoto Y.
中科院分区：
文献类型：
--
作者：
Yasukawa H;Oba T;Fukumoto Y.
恶性室性心律失常，包括室性心动过速和室颤（VF），是总死亡率和心血管死亡率的主要原因（1，2）。由这些室性心律失常引起的心源性猝死是一个重要的未解决的临床问题（1，2）。成人室性心律失常后的心源性猝死最常见的原因是心肌缺血或心肌梗死（MI）的后遗症（1）。流行病学研究表明，家庭成员的猝死是心源性猝死的危险因素（2）。两组研究人员比较了首次MI早期有和无VF的个体，发现猝死家族史是心肌缺血或MI期间心脏骤停的一个强风险因素（3，4）。这些报告表明，常见的遗传因素是心肌缺血或MI期间VF易感性的基础。全基因组关联研究是一种高通量基因分型方法，可用于搜索大量单核苷酸多态性（SNP）与表型性状之间的关联（5）。Bezzina等人(6)我用这种方法研究急性心肌梗死患者，集中于高度特异性的心肌梗死表型，以尽量减少异质性。
Malignant ventricular arrhythmias, including ventricular tachycardia and ventricular fibrillation (VF), are leading causes of total and cardiovascular mortality (1, 2). Sudden cardiac death resulting from these ventricular arrhythmias represents a significant unsolved clinical problem (1, 2). Sudden cardiac death after ventricular arrhythmia in adults is most frequently caused by the sequelae of myocardial ischemia or myocardial infarction (MI)(1). Epidemiological studies have indicated that sudden death of a family member is a risk factor for sudden cardiac death (2). Two groups have compared individuals with and without VF during the early phase of a first MI and found that family history of sudden death is a strong risk factor for cardiac arrest during myocardial ischemia or MI (3, 4). These reports suggest that common genetic factors underlie susceptibility to VF during myocardial ischemia or MI.Genome-wide association studies are a high-throughput genotyping method to search for associations between a large number of single-nucleotide polymorphisms (SNPs) and phenotypic traits (5). Bezzina et al.(6) used this method to investigate patients with acute MI, focusing on a highly specific arrhythmic phenotype to minimize heterogeneity.