Epidemiology of Dupuytren's disease -: Clinical, serological, and social assessment.: The Reykjavik Study
Epidemiology of Dupuytren's disease -: Clinical, serological, and social assessment.: The Reykjavik Study
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DOI：
10.1016/s0895-4356(99)00145-6
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发表时间：
2000-03-01
影响因子：
7.2
通讯作者：
Jónsson, T
中科院分区：
文献类型：
--
作者：
Gudmundsson, KG;Arngrímsson, R;Jónsson, T
Dupuytren病或掌纤维瘤病是一种常见的致残性手部疾病，主要局限于欧洲西北部的高加索人。对年龄在46岁至74岁之间的1297名男性和865名女性随机抽样进行Dupuytren病的患病率和可能的危险因素评估。采集血样，评价生化指标。用年龄调整的单变量logistic回归分析估计疾病与临床、社会和生化参数之间可能的关系。总共有19.2%的男性和4.4%的女性参与者有Dupuptren病的临床症状。患病率随年龄增长而增加，从45-49岁年龄组的7.2%上升到70-74岁年龄组的39.5%。更严重的疾病形式，手指挛缩，在5.0%的男性中被发现，1.4%的人需要手术，而这在女性中很少见。在男性中，空腹血糖升高（P < 0.04）、低体重和体重指数与该疾病的存在显著相关（P < 0.001）。Dupuytren病在重度吸烟者（P = 0.02）和体力劳动者（P = 0.018）中较为常见。这些结果表明，Dupuytren病在冰岛人群中很常见，职业和生活方式似乎与该疾病有关。(C) 2000 Elsevier Science Inc.；版权所有。
Dupuytren's disease or palmar fibromatosis is a common disabling hand disorder, mainly confined to Caucasians of northwestern European origin. The prevalence of Dupuytren's disease and possible risk factors related to the disease were evaluated in a random sample of 1297 males and 865 females, aged 46 to 74 years. Blood samples were collected and biochemical parameters were evaluated. The possible relation between the disease and clinical, social, and biochemical parameters were estimated with age-adjusted univariate logistic regression analysis. Altogether 19.2% of the males and 4.4% of the female participants had clinical signs of Dupuptren's disease. The prevalence increased with age, from 7.2% among males in the age group 45-49 years up to 39.5% in those 70-74 years old. The more severe form of the disease, finger contractures,was found in 5.0% of the men and 1.4% had required operation, while this was rarely seen among women. In men elevated fasting blood glucose (P < 0.04), low body weight, and body mass index were significantly correlated with the presence of the disease (P < 0.001). Dupuytren's disease was common among heavy smokers (P = 0.02) and those having manual labor as occupation (P = 0.018). These results show that Dupuytren's disease is common in the Icelandic population and occupation and lifestyle seem to be related to the disease. (C) 2000 Elsevier Science Inc. All rights reserved.