Enzyme-assisted waste-to-reactant transformation to engineer renewable DNA circuits
Enzyme-assisted waste-to-reactant transformation to engineer renewable DNA circuits
复制标题
酶辅助废物到反应物的转化设计可再生 DNA 电路
DOI：
10.1039/c9cc05941e
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发表时间：
2019
影响因子：
4.9
通讯作者：
Liang Haojun
中科院分区：
文献类型：
--
作者：
Li Xiang;Sun Xianbao;Zhou Junxiang;Yao Dongbao;Xiao Shiyan;Zhou Xiang;Wei Bing;Li Chengxu;Liang Haojun
到目前为止，由于包括反应物耗尽和废物积累在内的问题，可再生DNA电路的实施仍然具有挑战性。在这里，我们同时解决了这两个问题，通过切口酶辅助废物到反应物的转化。作为概念验证，实现了可再生的熵驱动的催化DNA电路，在补充燃料时表现出良好的可再生性。
To date, implementation of renewable DNA circuits remains challenging due to issues including reactant depletion and waste accumulation. Herein we simultaneously addressed both issues through nicking enzyme-assisted waste-to-reactant transformation. As a proof-of-concept, a renewable entropy-driven catalytic DNA circuit was implemented, exhibiting a good renewability when replenishing fuel.