The composition of the zebrafish intestinal microbial community varies across development
The composition of the zebrafish intestinal microbial community varies across development
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DOI：
10.1038/ismej.2015.140
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发表时间：
2016-03-01
期刊：
影响因子：
11
通讯作者：
Bohannan, Brendan J. M.
中科院分区：
文献类型：
--
作者：
Stephens, W. Zac;Burns, Adam R.;Bohannan, Brendan J. M.
常驻微生物群落的组装是动物发育中的重要事件;然而，该过程在多大程度上反映宿主组织的发育程序尚不清楚。在这里，我们调查了肠道细菌在关键的发展时间点，在一个兄弟姐妹组的135个人的模式脊椎动物，斑马鱼（Danio rerio）。我们的调查揭示了肠道微生物群的阶段特异性特征和广泛的个体间差异，即使在同一发育阶段。微生物群落的变化是明显的，在恒定的饮食和环境条件下，以及在演唱会与饮食和环境的变化。肠道菌群的个体间差异随着年龄的增长而增加，肠道菌群与周围环境中的微生物之间的差异也是如此。我们的研究结果表明，斑马鱼肠道微生物群在整个发育过程中聚集成不同的群落，这些群落与周围环境和彼此之间的差异越来越大。
The assembly of resident microbial communities is an important event in animal development; however, the extent to which this process mirrors the developmental programs of host tissues is unknown. Here we surveyed the intestinal bacteria at key developmental time points in a sibling group of 135 individuals of a model vertebrate, the zebrafish (Danio rerio). Our survey revealed stage-specific signatures in the intestinal microbiota and extensive interindividual variation, even within the same developmental stage. Microbial community shifts were apparent during periods of constant diet and environmental conditions, as well as in concert with dietary and environmental change. Interindividual variation in the intestinal microbiota increased with age, as did the difference between the intestinal microbiota and microbes in the surrounding environment. Our results indicate that zebrafish intestinal microbiota assemble into distinct communities throughout development, and that these communities are increasingly different from the surrounding environment and from one another.