Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
Cerebral white matter in early puberty is associated with luteinizing hormone concentrations
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DOI：
10.1016/j.psyneuen.2008.03.017
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发表时间：
2008-08-01
影响因子：
3.7
通讯作者：
Pol, Hilleke E. Hulshoff
中科院分区：
文献类型：
--
作者：
Peper, Jiska S.;Brouwer, Rachel M.;Pol, Hilleke E. Hulshoff
青春期是大脑白质大量生长，而灰质减少的时期。男孩和女孩青春期的第一个内分泌标志是黄体生成素 (LH) 分泌增加。在这里，我们研究了 104 名健康的 9 岁同卵双胞胎和异卵双胞胎中 LH、整体灰质和白质之间的表型关联。应用测压 MRI 和基于体素的形态测量来测量整体灰质和白质，并估计区域大脑的相对浓度。分别是灰质和白质。研究了这种关联（遗传相关性）的可能共同遗传起源。结果表明，较高的 LH 水平与较大的整体白质比例和较高的区域白质密度相关。白质密度增加的区域包括扣带回、颞中回和胼胝体压部。未发现 LH 与整体灰质比例或区域灰质密度之间存在关联。我们的数据表明，LH 水平与区域白质密度之间的关联存在一个常见的遗传因素。我们认为，早期报道的青春期白质生长的增加可能是由 LH 产生直接或间接介导的。此外，参与 LH 产生的基因可能是青春期早期发病的神经精神疾病的候选基因。 (c) 2008 Elsevier Ltd. 保留所有权利。
Puberty is a period in which cerebral white matter grows considerably, whereas gray matter decreases. The first endocrinological marker of puberty in both boys and girls is an increased secretion of luteinizing hormone (LH). Here we investigated the phenotypic association between LH, global and focal gray and white matter in 104 healthy nine-year-old monozygotic and dizygotic twins. Votumetric MRI and voxel-based morphometry were applied to measure global gray and white matter and to estimate relative concentrations of regional cerebral. gray and white matter, respectively. A possible common genetic origin of this association (genetic correlation) was examined. Results showed that higher LH levels are associated with a larger global white matter proportion and with higher regional white matter density. Areas of increased white matter density included the cingulum, middle temporal gyrus and splenium of the corpus callosum. No association between LH and global gray matter proportion or regional gray matter density was found. Our data indicate that a common genetic factor underlies the association between LH level and regional white matter density. We suggest that the increase of white matter growth during puberty reported earlier might be directly or indirectly mediated by LH production. In addition, genes involved in LH production may be promising candidate genes in neuropsychiatric illnesses with an onset in early adolescence. (c) 2008 Elsevier Ltd. All rights reserved.