Development of pH-responsive chitosan-based hydrogel modified with bone ash for controlled release of amoxicillin
Development of pH-responsive chitosan-based hydrogel modified with bone ash for controlled release of amoxicillin
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DOI：
10.1016/j.carbpol.2017.12.023
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发表时间：
2018-03-15
影响因子：
11.2
通讯作者：
Alemdar, Neslihan
中科院分区：
文献类型：
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作者：
Aycan, Didem;Alemdar, Neslihan
本研究通过壳聚糖接枝甲基丙烯酸缩水甘油酯(CTS-g-GMA)和聚乙二醇二丙烯酸酯(PEGDA)在紫外光下的光聚合，将骨灰包埋在凝胶结构中，得到骨灰增强的壳聚糖基水凝胶。用ATR-FTIR、扫描电子显微镜和X射线衍射仪对水凝胶进行了表征。用万能机械试验机测定了水凝胶的力学性能。用L929细胞株进行水凝胶的细胞毒性试验，以确定细胞的相容性。通过溶胀实验考察了水凝胶的吸水性能。模型药物选用可用于治疗胃溃疡的阿莫西林。阿莫西林在模拟胃液(pH：1.2)和肠道介质(pH：7.4)中以高效、可控的方式释放。这些结果表明，得到的pH敏感的壳聚糖基水凝胶具有更高的力学性能，在未来的应用中可能成为治疗胃溃疡的潜在药物载体。
In present study, bone ash-reinforced chitosan-based hydrogels were obtained by encapsulation of bone ash into the hydrogel structure which was fabricated by photopolymerization of chitosan-grafted-glycidyl methacrylate (CTS-g-GMA) and poly(ethylene glycol) diacrylate (PEGDA) under the UV light. Hydrogels were characterized by ATR-FTIR, SEM and XRD analyses. Mechanical performance of the hydrogels was determined by universal mechanical tester. Cytotoxicity tests for hydrogels were conducted with L929 cell lines to determine cellular compatibility. Swelling tests were carried out to investigate the water uptake capacity of hydrogels. Amoxicillin which could be used for treatment of gastric ulcer was selected as the model drug. The release of amoxicillin was provided at simulated gastric (pH: 1.2) and intestinal media (pH: 7.4) in efficient and controlled manner. All results visualized that the obtained pH-sensitive chitosan-based hydrogel with enhanced mechanical properties could be a potential candidate as a drug carrier for treatment of gastric ulcer in the future applications.