Ultrafine (nanometre) particle mediated lung injury
Ultrafine (nanometre) particle mediated lung injury
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DOI：
10.1016/s0021-8502(97)00464-3
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发表时间：
1998-06-01
影响因子：
4.5
通讯作者：
MacNee, W
中科院分区：
文献类型：
--
作者：
Donaldson, K;Li, XY;MacNee, W
实验研究表明，暴露于超细颗粒（例如二氧化钛或炭黑）的大鼠比暴露于由相同材料组成的相同沉积质量的细可吸入颗粒的大鼠遭受更多的肺损伤和病理。流行病学研究表明，环境中的空气污染（PM10）与肺部发病率和死亡率的一系列终点之间存在相关性，PM10颗粒的超细部分被认为是这些影响的主要媒介。根据迄今为止的研究，可以假设超细颗粒肺部沉积后的一系列事件。每单位质量的大量沉积颗粒可能超过巨噬细胞吞噬它们的能力，并且这允许颗粒和上皮细胞之间的长期相互作用可能是刺激炎症和颗粒间质转移的重要因素。由与肺接触的超细颗粒提供的大表面积为颗粒的表面化学提供了具有深远影响的机会。自由基，如羟基自由基，可以通过与PM10颗粒相关的过渡金属产生，导致氧化损伤和细胞刺激;颗粒表面的稳定自由基在其他类型的超细颗粒与细胞的相互作用中也可能是重要的。渗透到结缔组织的超细颗粒将与间质巨噬细胞和其他敏感细胞群接触，这可能具有强大的致炎作用，成为后续疾病发展的基础。(C)1998爱思唯尔科技有限公司版权所有。
Experimental studies have shown that rats exposed to ultrafine particles of, for example, titanium dioxide or carbon black, sustain more lung injury and pathology than rats exposed to the same deposited mass of fine respirable particles composed of the same material. Epidemiological studies have shown a correlation between environmental articulate air pollution (PM10) and a range of endpoints of lung morbidity and also mortality, and an ultrafine fraction of the PM10 particles is considered to be the principal mediator of these effects. A sequence of events following pulmonary deposition of ultrafine particles can be hypothesised, based on studies to date. The large number of deposited particles per unit mass may exceed the ability of macrophages to phagocytose them, and the prolonged interaction between the particles and epithelial cells that this allows may be an important factor in stimulating inflammation and interstitial transfer of the particles. The large surface area provided by ultrafine particles in contact with the lung provides the opportunity for surface chemistry of the particles to have a profound effect. Free radicals, such as hydroxyl radical, may be generated via transition metals associated with PM10 particles leading to oxidative damage and cell stimulation; stable radicals at the particle surface may also be important in the interactions of other types of ultrafine particles with cells. Ultrafine particles that penetrate to the interstitium will make contact with interstitial macrophages and other sensitive cell populations and this is likely to have a powerful inflammogenic effect that underlies development of subsequent disease. (C) 1998 Elsevier Science Ltd. All rights reserved.