Systems pharmacology to predict drug safety in drug development
Systems pharmacology to predict drug safety in drug development
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DOI：
10.1016/j.ejps.2016.05.027
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发表时间：
2016-10-30
影响因子：
4.6
通讯作者：
Mettetal, Jerome T.
中科院分区：
文献类型：
--
作者：
Trame, Mirjam N.;Biliouris, Konstantinos;Mettetal, Jerome T.
确保药物的安全性和有效性是药物开发和美国食品和药物管理局审查过程的高度优先事项。由于审批时间更快，临床试验规模更小，尤其是在肿瘤和罕见疾病方面，今天尤其如此。鉴于这些趋势，系统药理学被视为理解和预测药物开发过程中药物不良事件的基本策略，通过分析药物与多个靶点之间的相互作用，而不是传统的“一药一靶点”方法。本评论概述了使用系统药理学来减少意外不良事件风险的当前趋势和挑战。(C) 2016 Elsevier B.V.版权所有
Ensuring that drugs are safe and effective is a very high priority for drug development and the US Food and Drug Administration review process. This is especially true today because of faster approval times and smaller clinical trials, especially in oncology and rare diseases. In light of these trends, systems pharmacology is seen as an essential strategy to understand and predict adverse drug events during drug development by analyzing interactions between drugs and multiple targets rather than the traditional "one-drug-one-target' approach. This commentary offers an overview of the current trends and challenges of using systems pharmacology to reduce the risks of unintended adverse events. (C) 2016 Elsevier B.V. All rights reserved.