Role of Monocytes in Heart Failure and Atrial Fibrillation.
Role of Monocytes in Heart Failure and Atrial Fibrillation.
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DOI：
10.1161/jaha.117.007849
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发表时间：
2018-02-01
影响因子：
5.4
通讯作者：
Shantsila E
中科院分区：
文献类型：
--
作者：
Shahid F;Lip GYH;Shantsila E
心力衰竭(HF)是一种病理过程的高潮，表现为衰弱的症状，突出免疫、激素和代谢系统之间的复杂相互作用，导致心脏功能受损。心衰对患者的生活质量和寿命有重大影响。1在动物研究中，炎症已被证明在心力衰竭的发病机制中起关键作用，但将这些发现转化为人类研究的情况有限。2、3单核细胞和单核细胞来源的巨噬细胞在HF的发生发展中起一定作用。在人类免疫学中，单核细胞进行吞噬作用，以提供对外来病原体的保护，如细菌和病毒。然而，有一些不同的单核细胞亚群在心力衰竭的发病机制中具有潜在的有益或有害的影响，尽管所涉及的过程的密切细节尚未完全确定。4、5重要的是，单核细胞在心血管疾病中的作用是复杂的，包括炎症，炎症随后有助于再生、修复和调节血栓前状态的过程。6、7所有这些功能都与心力衰竭患者高度相关，这些患者表现为心功能进行性损害，并经常发生房颤(AF)，这是一种具有高血栓并发症风险的心律失常。因此，同样令人感兴趣的是免疫系统在房颤中的作用，房颤是心力衰竭中一种非常常见的心律失常，它与炎症密切相关。已有8例房颤患者出现心房和心室纤维化，
Heart failure (HF) is a culmination of pathological processes presenting with debilitating symptoms that highlight a complex interplay between immunological, hormonal, and metabolic systems resulting in impaired cardiac function. HF has a major impact on the quality of life and longevity of the affected patients. 1 Inflammation has been shown to play a pivotal role in the pathogenesis of HF within animal studies, but there has been limited translation of these findings into human research. 2, 3Monocytes and monocyte-derived macrophages play a role in the development of HF. In human immunology, monocytes undertake phagocytosis to provide protection from foreign pathogens such as bacteria and viruses. Nevertheless, there are distinct subsets of monocytes with potential for beneficial or detrimental effects on HF pathogenesis, although intimate details of the involved processes are not yet fully determined. 4, 5 Of importance is the fact that the role of monocytes in cardiovascular diseases is complex and includes inflammation, which subsequently contributes to processes of regeneration, repair, and modulation of the prothrombotic state. 6, 7 All these functions are highly relevant to patients with HF, who show progressive impairment of cardiac function and frequently develop atrial fibrillation (AF), an arrhythmia with a high risk of thrombotic complications. Therefore, of equal interest is the role of the immune system in AF, a very common arrhythmia in HF, which has been strongly linked to inflammation. 8 Atrial and ventricular fibrosis have been documented in patients with AF, with