Nicotine Metabolite Ratio (NMR) Prospectively Predicts Smoking Relapse: Longitudinal Findings From ITC Surveys in Five Countries
Nicotine Metabolite Ratio (NMR) Prospectively Predicts Smoking Relapse: Longitudinal Findings From ITC Surveys in Five Countries
复制标题
DOI：
10.1093/ntr/ntx083
复制
发表时间：
2017-09-01
影响因子：
4.7
通讯作者：
Thrasher, James F.
中科院分区：
文献类型：
--
作者：
Fix, Brian V.;O'Connor, Richard J.;Thrasher, James F.
前言：反式3‘-羟基可替宁(3HC)与可替宁(Cotinine)的比值(NAMR)是尼古丁代谢率的生物标志物，NMR值越高，代谢越快。在戒烟试验中，较高的核磁共振被发现与较高的日常香烟消耗量和较低的戒烟成功率有关。本研究检验了这五个国家基于人群的吸烟者核磁共振的差异，并探索了核磁共振与戒烟的关系。方法：受试者(N=874)提供了2010/2011年在美国、英国、毛里求斯、墨西哥和泰国进行的国际烟草控制(ITC)调查期间的唾液样本，并于2012/2013年进行了跟踪调查。结果：不同国家的核磁共振谱有显著差异(F=15.49，P<0.05)。
Introduction: The ratio of trans 3'-hydroxycotinine (3HC) to cotinine (nicotine metabolite ratio [NMR]) is a biomarker of the rate of nicotine metabolism, with higher NMR indicating faster metabolism. Higher NMR has been found to be associated with higher daily cigarette consumption and less success stopping smoking in cessation trials. This study examines differences in NMR among population-based samples of smokers in the five countries and explores the relationship between NMR and smoking abstinence.Methods: Participants (N = 874) provided saliva samples during International Tobacco Control (ITC) surveys in the United States, United Kingdom, Mauritius, Mexico, and Thailand conducted in 2010/2011 with follow-up surveys in 2012/2013. When all samples were received, they were sent to a common laboratory for analysis using liquid chromatography and tandem mass spectroscopy.Results: There was significant variation in NMR across countries (F = 15.49, p