Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes
Relationship between selected indoor volatile organic compounds, so-called microbial VOC, and the prevalence of mucous membrane symptoms in single family homes
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DOI：
10.1016/j.scitotenv.2010.02.012
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发表时间：
2010-04-15
影响因子：
9.8
通讯作者：
Kishi, Reiko
中科院分区：
文献类型：
--
作者：
Araki, Atsuko;Kawai, Toshio;Kishi, Reiko
众所周知，微生物会产生一系列挥发性有机化合物，即所谓的微生物挥发性有机化合物（MVOC）。人体暴露于MVOC的室内研究解决了客观和/或主观粘膜刺激迹象的急性影响。本流行病学研究的目的是测量单户住宅室内多挥发性有机化合物的水平，并评估暴露于多挥发性有机化合物与病态建筑综合征（SBS）之间的关系。所有住宅居民都填写了一份自填问卷，其中包含评估其症状的标准化问题，收集了空气样本，并对室内空气中8种选定化合物的浓度进行了测定采用气相色谱/质谱选择性离子监测模式（GC/MS-SIM）分析。最常检出的MVOC为1-戊醇，检出率为78.6%，几何平均值为060 μ g/m(3)。在620名参与者中，120名（19.4%）报告了一种或多种粘液症状；每周都有眼睛、鼻子、气道发炎或咳嗽（每周症状），30人（4.8%）报告症状与家庭有关（家庭相关症状）。每周症状与任何MVOC无关。然而，在对性别、年龄和吸烟进行校正后，与家庭相关的粘膜症状与1-辛烯-3-醇(每对数（10)-单位：比值比（OR） 5.6, 95%置信区间（Cl） 21至14.8）和2-戊醇(每对数（10)-单位：比值比（OR） 2.3, 95% CI 10至4.9）之间存在显著关联。家庭相关症状与1-辛烯-3-醇之间的相关性在相互调节后仍然存在。然而，所选化合物在室内的浓度低于动物研究中估计的安全水平。因此，1-辛烯-3-醇之间的统计显著关联可能是由于化合物的直接作用，或者这种关联可能与其他有害化合物有关。需要进一步的研究来评估这些可能性。(C) 2010 Elsevier B.V.版权所有
Microorganisms are known to produce a range of volatile organic compounds, so-called microbial VOC (MVOC). Chamber studies where humans were exposed to MVOC addressed the acute effects of objective and/or subjective signs of mucosal irritation However, the effect of MVOC on inhabitants due to household exposure is still unclear The purpose of this epidemiological study was to measure indoor MVOC levels in single family homes and to evaluate the relationship between exposure to them and sick building syndrome (SBS) All Inhabitants of the dwellings were given a self-administered questionnaire with standardized questions to assess their symptoms Air samples were collected and the concentrations of eight selected compounds in indoor air were analyzed by gas chromatography/mass spectrometry selective ion monitoring mode (GC/MS-SIM). The most frequently detected MVOC was 1-pentanol at a detection rate of 78 6% and geometric mean of 060 mu g/m(3). Among 620 participants, 120 (19.4%) reported one or more mucous symptoms; irritation of the eyes, nose, airway, or coughing every week (weekly symptoms), and 30 (4 8%) reported that the symptoms were home-related (home-related symptoms). Weekly symptoms were not associated with any of MVOC. whereas significant associations between home-related mucous symptoms and 1-octen-3-ol (per log(10)-unit: odds ratio (OR) 5 6, 95% confidence interval (Cl) 21 to 14.8) and 2-pentanol (per log(10)-unit OR 2.3, 95% CI 1 0 to 4.9) were obtained after adjustment for gender, age, and smoking. Associations between home-related symptoms and 1-octen-3-ol remained after mutual adjustment. However, concentrations of the selected compounds in indoors were lower than the estimated safety level in animal studies. Thus, the statistically significant association between 1-octen-3-ol may be due to a direct effect of the compounds or the associations may be being associated with other offending compounds. Additional studies are needed to evaluate these possibilities. (C) 2010 Elsevier B.V. All rights reserved