Inositol phosphate synthesis and the nuclear processes they affect
Inositol phosphate synthesis and the nuclear processes they affect
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DOI：
10.1016/j.ceb.2010.03.006
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发表时间：
2010-06-01
影响因子：
7.5
通讯作者：
York, John D.
中科院分区：
文献类型：
--
作者：
Monserrate, Jessica P.;York, John D.
最近的研究表明，肌醇磷酸，一个高电荷的脂质衍生代谢产物家族，参与了许多细胞过程。然而，正是他们参与核事件引起了人们的广泛关注。一些IP分子已经与基因调控因子、染色质重塑复合物、mRNA输出和DNA修复机制相关，但在许多情况下，直接的机制作用仍然难以捉摸。本次审查的目的是涵盖最新的数据收集有关的各种肌醇磷酸的核作用，同时提供了一个一步一步的IP合成真核生物。
Recent studies have implicated inositol phosphates, a highly charged family of lipid-derived metabolites, in a slue of cellular processes. However, it is their involvement in nuclear events that has attracted much attention. Several IP molecules have been linked to gene regulatory factors, chromatin-remodeling complexes, mRNA export, and DNA repair machinery, yet in many instances direct mechanistic roles remain elusive. The purpose of this review is to cover the latest data gathered regarding only the nuclear roles of the various inositol phosphates while simultaneously providing a step-by-step tour of IP synthesis in eukaryotes.