Synthesis and Characterization of a (Dipyridylthiophene)platin Complex of a Pyridyl-Substituted Aminoethylglycine Artificial Dipeptide
Synthesis and Characterization of a (Dipyridylthiophene)platin Complex of a Pyridyl-Substituted Aminoethylglycine Artificial Dipeptide
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吡啶基取代氨乙基甘氨酸人工二肽（二吡啶基噻吩）铂配合物的合成与表征
DOI：
10.1002/ejic.200800585
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发表时间：
2008
影响因子：
2.3
通讯作者：
M. E. Williams
中科院分区：
文献类型：
--
作者：
Lauren A. Levine;H. Youm;H. Yennawar;M. E. Williams
我们报道了一种由2，5-二（2-吡啶基）噻吩（dpt）铂配合物交联的人工吡啶基取代二肽的液相合成和表征。合成Pt（dpt）联吡啶基-肽的小分子等效物用于比较。通过二维和变温核磁共振、质谱、电化学、紫外/维斯吸收光谱和发射光谱对这些化合物进行了表征，并比较了它们的光电发射动力学。配合物有两个可逆的，配体为中心的减少，在室温下发光，并有两个不同的辐射弛豫纳秒和微秒的寿命。这些金属化的肽结构单元有希望用作稳定的无机络合物，以标记具有发光和氧化还原活性的探针的合成肽。（© Wiley-VCH Verlag GmbH & Co. KGaA，69451魏因海姆，德国，2008）
We report the solution-phase synthesis and characterization of an artificial pyridyl-substituted dipeptide that is crosslinked by a 2,5-bis(2-pyridyl)thiophene (dpt) platinum complex. The small molecule equivalent for the Pt(dpt)dipyridyl-peptide is synthesized for comparison. These compounds are characterized by two-dimensional and variable-temperature NMR, mass spectrometry, electrochemistry, UV/Vis absorbance and emission spectroscopy, and their photoemission dynamics are compared. The complexes have two reversible, ligand-centered reductions, are luminescent at room temperature, and have two distinct radiative relaxations with nanosecond and microsecond lifetimes. These metallated peptide building blocks are promising for use as stable inorganic complexes to label synthetic peptides with luminescent and redox-active probes.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2008)
影响因子：
7.3
作者：
Ana Paula Soares Fontes;Ramani Bandarage;Nicholas Farrell;Y. Qu;H. Rauter;Lloyd R. Kelland
通讯作者：
Ana Paula Soares Fontes;Ramani Bandarage;Nicholas Farrell;Y. Qu;H. Rauter;Lloyd R. Kelland