Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy
Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy
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DOI：
10.1007/s00520-003-0512-2
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发表时间：
2003-10-01
影响因子：
3.1
通讯作者：
Thiel, E
中科院分区：
文献类型：
--
作者：
Dimeo, F;Schwartz, S;Thiel, E
疲倦和身体机能受损是癌症患者在治疗过程中和治疗后常见的，有时甚至是严重的问题。为了避免疲劳，癌症患者经常被建议休息并减少日常活动。然而，这些建议可能会导致自相矛盾的结果。由于缺乏运动会导致肌肉萎缩，长时间的休息可能会导致进一步的耐力丧失。最近的研究表明，锻炼，以及行为和一些心理社会干预，可能会减少疲劳，改善癌症患者的表现状况。在本文中，我们回顾了治疗癌症相关性疲劳的干预措施，并介绍了一项关于运动对恶性血液病患者体能的影响的研究结果。66名住院患者(34名男性，32名女性)接受常规(n=45)或大剂量化疗联合干细胞拯救(n=21)，以治疗每天在跑步机上锻炼的血液系统恶性肿瘤。在入院时和住院期间(30+/-10天，范围10-49)每周评估一次体能表现。尽管化疗及其相关并发症，但在次最大标准负荷试验中(入院时：5.5+/-1.4公里/小时；住院中期：5.3+/-1.3公里/小时；出院时：5.5+/-1.3公里/小时；p=0.60)，体能表现保持不变。平均血红蛋白浓度显著降低(从入院时的10.3+/-2.0g/dl降至出院时的9.6+/-1.2g/dl；p=0.03)。我们的结论是，每天的耐力训练计划可以减少接受化疗的血液系统恶性肿瘤患者与治疗相关的体能丧失。
Fatigue and impaired physical performance are common and sometimes serious problems of cancer patients during and after treatment. To avoid fatigue, cancer patients are often advised to rest and downregulate their daily activities. However, these recommendations can cause paradoxical results. Since inactivity induces muscular wasting, prolonged rest can result in further loss of endurance. Recent studies suggest that exercise, as well as behavioral and some psychosocial interventions, may reduce fatigue and improve the performance status of cancer patients. In this paper, we review interventions proposed for the treatment of cancer-related fatigue and present the results of a study about the effects of exercise on the physical performance of patients with hematological malignancies. Sixty-six inpatients (34 men, 32 women) undergoing conventional (n=45) or high-dose chemotherapy with stem cell rescue (n=21) for the treatment of a hematological malignancy exercised daily on a treadmill. Physical performance was assessed on admission and once a week during hospitalization (30+/-10 days, range 10-49). Physical performance remained unchanged in a submaximal standard stress test (on admission: 5.5+/-1.4 km/h; midhospitalization: 5.3+/-1.3 km/h; at discharge: 5.5+/-1.3 km/h; p=0.60) despite chemotherapy and its related complications. A significant decrease in the mean hemoglobin concentration (from 10.3+/-2.0 g/dl on admission to 9.6+/-1.2 g/dl at discharge; p=0.03). We conclude that a daily endurance-training program reduces the treatment-related loss of physical performance in patients with hematological malignancies undergoing chemotherapy.