Minisatellite origins in yeast and humans
Minisatellite origins in yeast and humans
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DOI：
10.1006/geno.1997.5153
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发表时间：
1998-02-15
期刊：
影响因子：
4.4
通讯作者：
Louis, EJ
中科院分区：
文献类型：
--
作者：
Haber, JE;Louis, EJ
可变数目的串联重复序列在遗传学研究中是有价值的标记。感兴趣的阵列是简单的微卫星，包含1-5个核苷酸的重复，和小卫星，具有大约10至100 bp的多次迭代。微卫星起源可以解释为偶然包含两个或多个相邻短重复序列的区域中的复制错误。微卫星变异是由于复制错误和缺乏错配校正而引起的。Parsons等人，1993，Cell 75：1227-1236; M. Strand等人，1993，Nature 365：274-276）。小卫星大小的变化被认为涉及同源重组过程，包括基因转换（J. Buard和G. Vergnaud，1994，EMBO J. 13：3203-3210; A. J. Jeffreys等人，1994，Nature Genet. 6：136-145）和可能的不平等交换之间的重复。然而，小卫星的起源并不那么明显。单凭偶然发现小卫星大小的直接串联重复序列的概率非常低[
Variable numbers of tandem repeats are valuable markers in genetic studies. The arrays of interest are simple microsatellites, containing repetitions of 1-5 nucleotides, and minisatellites, with multiple iterations of approximately 10 to 100 bp. Microsatellite origins can be explained by replication errors in regions fortuitously containing two or more adjacent short repeats. Microsatellite variation arises by replication errors lan the absence of mismatch correction (a. Parsons et al., 1993, Cell 75: 1227-1236; M. Strand et ab., 1993, Nature 365: 274-276). Variation in the size of minisatellites is thought to involve homologous recombination processes, including gene conversions (J. Buard and G. Vergnaud, 1994, EMBO J. 13: 3203-3210; A. J. Jeffreys et al., 1994, Nature Genet. 6: 136-145) and possibly unequal exchanges among repeats. However, the origins of minisatellites are less obvious. The probability of finding a direct tandem repeat of minisatellite size by chance alone is very low [