Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease
Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease
复制标题
DOI：
10.1016/j.jns.2005.11.034
复制
发表时间：
2006-04-15
影响因子：
4.4
通讯作者：
Murayama, S
中科院分区：
文献类型：
--
作者：
Mitsui, J;Saito, Y;Murayama, S
在日本，I-123-间碘苄胍（MIBG）脑电成像中心脏摄取减少已被用作帕金森病（PD）最可靠的诊断试验之一。为了研究这一发现的形态学基础，我们对一名71岁尸检证实的PD患者的心脏交感神经系统进行了详细的神经病理学研究，该患者在死亡前1年心脏对MIBG的摄取明显减少。我们仔细检查了胸脊髓的几个水平的中间外侧柱，交感干和神经节，以及左心室前壁的神经丛，并将结果与5名年龄匹配的对照组进行了比较。我们发现，心脏神经丛是更严重的参与比交感神经节在这个病人与PD。我们的研究可能提供进一步的证据表明，在PD病例中观察到的MIBG的心脏摄取的显着降低代表心脏交感神经丛在这种疾病中的优先参与。(c)2005 Elsevier B. V.保留所有权利。
Decreased cardiac uptake in I-123-metaiodobenzylguanidine (MIBG) scintigraphy has been adopted as one of the most reliable diagnostic tests for Parkinson disease (PD) in Japan. To investigate the morphological basis for this Finding, we performed a detailed neuropathological Study of the cardiac sympathetic nervous system of a 71-year-old autopsy-proven PD patient, who presented with a marked decrease in cardiac uptake of MIBG, just 1 year prior to death. We carefully examined the intermediolateral Column at several levels of the thoracic spinal cord, the sympathetic trunk and ganglia, and the nerve Plexus of the anterior wall of the left ventricle and compared the findings with those of five age-matched controls. We found that the cardiac plexus was more heavily involved than the sympathetic ganglia in this patient with PD. Our study may provide further evidence that the markedly decreased cardiac uptake of MIBG observed in PD cases represents preferential involvement of the cardiac sympathetic nerve Plexus in this disorder. (c) 2005 Elsevier B.V. All rights reserved.