Epidemiology of Gout in Women Fifty-two-Year Followup of a Prospective Cohort
Epidemiology of Gout in Women Fifty-two-Year Followup of a Prospective Cohort
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DOI：
10.1002/art.27338
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发表时间：
2010-04-01
影响因子：
--
通讯作者：
Choi, Hyon
中科院分区：
文献类型：
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作者：
Bhole, Vidula;de Vera, Mary;Choi, Hyon
目标。尽管最近痛风在妇女中的发病率翻了一番，特别是在老龄化的女性人口中，痛风的患病率很高，但妇女痛风的危险因素仍然不清楚。我们开展了这项研究，以评估女性痛风事件的所谓危险因素，并将它们与男性的痛风事件进行比较。使用弗雷明翰心脏研究的前瞻性数据，我们在长达52年的时间里(1950-2002年)对2476名女性和1951名男性的痛风发病率与所谓的危险因素之间的关系进行了研究。我们记录了304例痛风事件，其中104例是女性。按血尿酸水平计算，女性每千人年痛风发病率分别为0.8、2.5、4.2、13.1和2 7.3(趋势与t；0.0001)。这种关联的程度低于男性(交互作用P=0.0002)。年龄增加(每5年)、肥胖(体重指数=30 kg/m(2))、饮酒(每周饮酒7盎司)、高血压和利尿剂的多因素相对危险度分别为1.24、2.74、3.10、1.82和2.39(均P<；0.05)。这些长期随访的前瞻性数据提供了证据，表明血清尿酸水平越高，女性患痛风的风险就越高，但增加的速度比男性低。年龄增加、肥胖、饮酒、高血压和利尿剂的使用与女性痛风事件的风险相关。
Objective. Despite the recent doubling of the incidence of gout among women and its substantial prevalence particularly in the aging female population, the risk factors for gout among women remain unknown. We undertook this study to evaluate purported risk factors for incident gout among women and to compare them with those among men.Methods. Using prospective data from the Framingham Heart Study, we examined over a 52-year period (1950-2002) the relationship between purported risk factors and the incidence of gout in 2,476 women and 1,951 men.Results. We documented 304 incident cases of gout, 104 of them among women. The incidence rates of gout for women per 1,000 person-years according to serum uric acid levels of = 8.0 mg/dl were 0.8, 2.5, 4.2, 13.1, and 27.3, respectively (P for trend < 0.0001). The magnitude of this association was lower than that among men (P for interaction = 0.0002). Multivariate relative risks conferred by increasing age (per 5 years), obesity (body mass index >= 30 kg/m(2)), alcohol intake (>= 7 ounces of pure alcohol/week), hypertension, and diuretic use were 1.24, 2.74, 3.10, 1.82, and 2.39, respectively (all P < 0.05), for women.Conclusion. These prospective data with long-term followup provide evidence that higher levels of serum uric acid increase the risk of gout in a graded manner among women, but the rate of increase is lower than that among men. Increasing age, obesity, alcohol consumption, hypertension, and diuretic use were associated with the risk of incident gout among women.