Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration
Acid-sensing ion channel 2 is important for retinal function and protects against light-induced retinal degeneration
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DOI：
10.1523/jneurosci.4698-03.2004
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发表时间：
2004-02-04
影响因子：
5.3
通讯作者：
Waldmann, R
中科院分区：
文献类型：
--
作者：
Ettaiche, M;Guy, N;Waldmann, R
视网膜 pH 值的变化被认为与视觉感知的微调有关。我们发现小鼠视网膜的光感受器和神经元都表达 H+ 门控阳离子通道亚基酸敏感离子通道 2a (ASIC2a) 和 ASIC2b。小鼠体内 ASIC2 基因失活会导致视杆视网膜电图 a 波和 b 波增加，从而增强视觉转导增益。 ASIC2 敲除小鼠对光诱导的视网膜变性也更敏感。我们认为 ASIC2 是视杆细胞光转导的负调节剂，功能性 ASIC2 通道有利于维持视网膜完整性。
pH variations in the retina are thought to be involved in the fine-tuning of visual perception. We show that both photoreceptors and neurons of the mouse retina express the H+-gated cation channel subunits acid-sensing ion channel 2a (ASIC2a) and ASIC2b. Inactivation of the ASIC2 gene in mice leads to an increase in the rod electroretinogram a- and b-waves and thus to an enhanced gain of visual transduction. ASIC2 knock-out mice are also more sensitive to light-induced retinal degeneration. We suggest that ASIC2 is a negative modulator of rod phototransduction, and that functional ASIC2 channels are beneficial for the maintenance of retinal integrity.