Insights into cognitive deficits caused by low-dose toxic heavy metal mixtures and their remediation through a postnatal enriched environment in rats
Insights into cognitive deficits caused by low-dose toxic heavy metal mixtures and their remediation through a postnatal enriched environment in rats
复制标题
深入了解低剂量有毒重金属混合物引起的认知缺陷及其通过出生后富集环境的修复
DOI：
10.1016/j.jhazmat.2020.122081
复制
发表时间：
2020
影响因子：
13.6
通讯作者：
Fan Guangqin
中科院分区：
文献类型：
--
作者：
Zhou Fankun;Yin Guangming;Gao Yanyan;Ouyang Lu;Liu Sisi;Jia Qiyue;Yu Han;Zha Zhipeng;Wang Kai;Xie Jie;Fan Ying;Shao Lijian;Feng Chang;Fan Guangqin
重金属，即铅（Pb），镉（Cd）和汞（Hg），已在各种独立研究中进行了广泛的研究。人们已经看到，这些金属通常在人体血液中同时检测到低水平。然而，目前尚不清楚暴露于这些重金属混合物（MM）是否会在这些低水平下引起神经损伤。因此，我们研究了铅，镉，汞的混合物对神经系统的影响，在大鼠的暴露剂量相当于那些通常在人体血液中发现的。在整个妊娠期和哺乳期通过饮用水使妊娠大鼠暴露于MM后，对其后代进行随访直至成年。MM以剂量依赖性方式引起认知缺陷和损伤。此外，MM破坏了树突棘，学习和记忆的结构基础，并诱导了棘相关通路的变化。与此同时，我们探索了一种早期和安全的方法来弥补这些损害，通过产后丰富的环境。丰富的环境改善MM受损的认知功能，突触可塑性，和脊柱相关的途径。本研究表明，低剂量铅、镉、汞联合暴露可导致认知和突触可塑性缺陷，通过丰富环境进行及时干预具有一定的矫正作用。
The heavy metals, namely lead (Pb), cadmium (Cd), and mercury (Hg), have been studied extensively in various independent studies. It has been seen that these metals are usually detected simultaneously in the human blood at low levels. However, it is unknown whether exposure to these heavy metal mixtures (MM) can induce neurological damages at these low levels. Therefore, we investigated the influence of the Pb, Cd, and Hg mixture on the nervous system in rats at exposure doses equivalent to those normally found in the human blood. After pregnant rats being exposed to MM via drinking water throughout the gestation and lactation, their offspring were followed-up till adulthood. MM caused cognitive deficits and impairments in a dose-dependent manner. Furthermore, MM disrupted dendritic spines, the structural basis of learning and memory, and induced changes in spine-related pathways. Meanwhile, we explored an early and safe way to remedy these impairments through a postnatal enriched environment. The enriched environment ameliorated MM-impaired cognitive function, synaptic plasticity, and spine-related pathways. This study demonstrated that low-dose co-exposure to Pb, Cd, and Hg can cause cognitive and synaptic plasticity deficits and timely intervention through the enriched environment has a certain corrective effect.